Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15534816 | 0.87 | P2RX7 (0.47) | DRD2TAS1R3TAS1R1HTR3EHTR3B | |
| SCHEMBL15534876 | 0.82 | DRD2 (0.38) | DRD2TAS1R3TAS1R1L3MBTL1HPGD | |
| SCHEMBL1666992 | 0.81 | ALDH1A1 (0.46) | DRD2HPGDHTR3EHTR3BHTR3A | |
| SCHEMBL1666286 | 0.71 | SLC6A2 (0.40) | TAAR1HPGDKDM4EALDH1A1 | |
| SCHEMBL22447716 | 0.71 | DRD2 (0.44) | DRD2POLBHPGDHTR3EHTR3B | |
| SCHEMBL2241114 | 0.70 | HPGD (0.63) | POLBL3MBTL1TAAR1HPGDKDM4E | |
| SCHEMBL1558671 | 0.69 | CA12 (0.52) | POLBTAAR1HPGDKDM4EALDH1A1 | |
| SCHEMBL1558070 | 0.69 | CA12 (0.52) | POLBTAAR1HPGDKDM4EALDH1A1 | |
| SCHEMBL1668136 | 0.69 | HPGD (0.50) | L3MBTL1HPGDKDM4EALDH1A1 | |
| SCHEMBL12986205 | 0.69 | AAK1 (0.41) | TAS1R3TAS1R1HTR4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013177349-A2 | QUINAZOLINEDIONES AS TANKYRASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-11-28 | — | — | WO | disclosed |