Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12799202 | 0.81 | MEN1 (0.40) | HTR2AHTR2CHTR2BALDH1A1MAPT | |
| SCHEMBL11893667 | 0.81 | MEN1 (0.40) | HTR2AHTR2CHTR2BALDH1A1MAPT | |
| SCHEMBL11893668 | 0.81 | MEN1 (0.40) | HTR2AHTR2CHTR2BALDH1A1MAPT | |
| SCHEMBL1666992 | 0.77 | ALDH1A1 (0.46) | SLC6A2SLC6A4KDM4EALDH1A1HPGD | |
| SCHEMBL15535647 | 0.71 | DRD2 (0.47) | KDM4EALDH1A1HPGDTAAR1 | |
| SCHEMBL15534816 | 0.71 | P2RX7 (0.47) | DPP4 | |
| SCHEMBL23022877 | 0.70 | CTSK (0.47) | SLC6A2SLC6A4KDM4EALDH1A1MAPT | |
| SCHEMBL1666875 | 0.68 | TAAR1 (0.41) | KDM4EALDH1A1HPGDHSD17B10TAAR1 | |
| SCHEMBL15534876 | 0.68 | DRD2 (0.38) | SLC6A2SLC6A4KDM4EALDH1A1HPGD | |
| SCHEMBL13918262 | 0.67 | SLC6A2 (0.42) | SLC6A2SLC6A4CYP3A4CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2485728-A1 | WNT PATHWAY ANTAGONISTS | Siena Biotech S.p.a. (IT) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011042145-A1 | WNT PATHWAY ANTAGONISTS | SIENA BIOTECH S.P.A. (IT) | 2011-04-14 | — | — | WO | disclosed |