Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.59 |
| ▸ | CFTR | P13569 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.53 |
| ▸ | HPGD | P15428 | 7/20 | 0.53 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | FADS1 | O60427 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10585897 | 0.82 | KDM4E (0.55) | ALDH1A1HSD17B10KDM4EHPGDTP53 | |
| SCHEMBL2160841 | 0.81 | ALDH1A1 (0.65) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL143432 | 0.81 | ALDH1A1 (0.49) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL10785014 | 0.81 | ALDH1A1 (0.49) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL692347 | 0.79 | ALDH1A1 (0.66) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL28102741 | 0.79 | ALDH1A1 (0.51) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL3636008 | 0.79 | NPC1 (0.65) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL27755279 | 0.78 | AKR1C3 (0.50) | ALDH1A1RAB9ANPC1 | |
| SCHEMBL30823003 | 0.78 | NPC1 (0.49) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL7963355 | 0.78 | ALDH1A1 (0.62) | ALDH1A1HSD17B10CFTRKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102124000-B | Pyridine compounds | ASTRAZENECA AB | 2014-09-17 | — | — | CN | disclosed |
| EP-2303861-B1 | PYRIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2014-04-23 | — | — | EP | disclosed |
| US-8569298-B2 | Pyridine compounds | ASTRAZENECA AB (SE) | 2013-10-29 | — | — | US | disclosed |
| CN-102124000-A | Pyridine compounds | ASTRAZENECA AB | 2011-07-13 | — | — | CN | disclosed |
| US-20110166139-A1 | PYRIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2011-07-07 | — | — | US | disclosed |
| EP-2303861-A1 | PYRIDINE COMPOUNDS | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009153589-A1 | PYRIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166139-A1 | PYRIDINE COMPOUNDS | PTK2, PTK2B, PFKP | ALDH1A1 2505/4885HSD17B10 4826/4885CFTR 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.