Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19249969 | 0.76 | TDO2 (0.33) | PIM1GPR84 | |
| SCHEMBL22050218 | 0.76 | MPO (0.33) | GPR84 | |
| Hydrochloric Acid SCHEMBL21988072 | 0.74 | MPO (0.32) | GPR84 | |
| SCHEMBL23147810 | 0.72 | CCNT1 (0.38) | CCNT1PIM1CDK9HASPIN | |
| SCHEMBL29958049 | 0.72 | TRIM24 (0.45) | CCNT1PIM1CDK9HASPINGPR84 | |
| SCHEMBL22050219 | 0.72 | CSNK2A2 (0.38) | AXL | |
| SCHEMBL30771272 | 0.71 | POLB (0.34) | CCNT1PIM1CDK9HASPIN | |
| SCHEMBL22688651 | 0.69 | GPR84 (0.58) | GPR84 | |
| SCHEMBL23658612 | 0.69 | GPR84 (0.58) | AXLGPR84 | |
| SCHEMBL22050704 | 0.69 | ALDH1A1 (0.41) | PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9163021-B2 | Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors | PFIZER LIMITED (GB) | 2015-10-20 | — | — | US | disclosed |
| US-9163021-B2 | Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors | PFIZER LIMITED (GB) | 2015-10-20 | — | — | US | disclosed |
| US-9163021-B2 | Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors | PFIZER LIMITED (GB) | 2015-10-20 | — | — | US | disclosed |
| US-20150246912-A1 | Pyrrolo[3,2-C]Pyridine Tropomyosin-Related Kinase Inhibitors | PFIZER LIMITED (GB) | 2015-09-03 | — | — | US | disclosed |
| US-20150246912-A1 | Pyrrolo[3,2-C]Pyridine Tropomyosin-Related Kinase Inhibitors | PFIZER LIMITED (GB) | 2015-09-03 | — | — | US | disclosed |
| US-20150246912-A1 | Pyrrolo[3,2-C]Pyridine Tropomyosin-Related Kinase Inhibitors | PFIZER LIMITED (GB) | 2015-09-03 | — | — | US | disclosed |
| EP-2912036-A1 | PYRROLO[3,2-C]PYRIDINE TROPOMYOSIN-RELATED KINASE INHIBITORS | Pfizer Limited (GB) | 2015-09-02 | — | — | EP | disclosed |
| WO-2014053968-A1 | PYRROLO[3,2-C]PYRIDINE TROPOMYOSIN-RELATED KINASE INHIBITORS | PFIZER LIMITED (GB) | 2014-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246912-A1 | Pyrrolo[3,2-C]Pyridine Tropomyosin-Related Kinase Inhibitors | MUSK, TPM3, DMPK | CCNT1 1847/4885PIM1 308/4885CDK9 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.