Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ATP4A | P20648 | 2/20 | 0.39 |
| ▸ | ATP4B | P51164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3017678 | 0.87 | BDKRB2 (0.81) | BDKRB2 | |
| SCHEMBL1563785 | 0.83 | BDKRB2 (0.85) | BDKRB2 | |
| SCHEMBL13145062 | 0.74 | BDKRB2 (1.00) | BDKRB2 | |
| SCHEMBL5440649 | 0.73 | LMNA (0.59) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL10904420 | 0.73 | GAA (0.47) | ALDH1A1GAAHPGDSMN1; SMN2LMNA | |
| SCHEMBL29420526 | 0.72 | NQO2 (0.54) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL1564603 | 0.72 | NQO2 (0.54) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL11824198 | 0.68 | CYP2A6 (0.40) | BDKRB2ALDH1A1LMNAMAPT | |
| SCHEMBL9405397 | 0.68 | NPC1 (0.49) | BDKRB2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL14237644 | 0.68 | MAOA (0.41) | BDKRB2KDM4EALDH1A1GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410134-B2 | 8-oxy-quinoline derivatives as bradykinin B2 receptor modulators | SHIRE ORPHAN THERAPIES GMBH (DE) | 2013-04-02 | — | — | US | disclosed |
| EP-2305668-A1 | 8-oxy-quinoline derivatives as bradykinin B2 receptor modulators | Jerini AG (DE) | 2011-04-06 | — | — | EP | disclosed |
| EP-2144897-B1 | 8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS | JERINI AG (DE) | 2010-10-20 | — | — | EP | disclosed |
| US-20100234344-A1 | 8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS | JERINI AG (DE) | 2010-09-16 | — | — | US | disclosed |
| EP-2144897-A1 | 8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS | Jerini AG (DE) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008116620-A1 | 8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS | JERINI AG (DE) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234344-A1 | 8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS | BDKRB2, BDKRB1, HRH2 | BDKRB2 1/4885KDM4E 3399/4885ALDH1A1 3393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.