Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841507 | 0.84 | IDO1 (0.55) | IDO1TAAR1ALDH1A1MAPTRAB9A | |
| SCHEMBL29765549 | 0.80 | PYCR1 (0.37) | IDO1ALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL1567609 | 0.80 | PYCR1 (0.37) | IDO1ALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL31009547 | 0.80 | ALOX15 (0.31) | — | |
| SCHEMBL30562820 | 0.79 | GAA (0.31) | IDO1ALDH1A1HTT | |
| SCHEMBL3301640 | 0.79 | GAA (0.31) | IDO1ALDH1A1HTT | |
| SCHEMBL3085103 | 0.77 | IDO1 (0.31) | IDO1 | |
| SCHEMBL1146014 | 0.77 | IDO1 (0.61) | IDO1TAAR1ALDH1A1MAPTRAB9A | |
| SCHEMBL9419161 | 0.76 | IDO1 (0.41) | IDO1TAAR1ALDH1A1MAPTRAB9A | |
| SCHEMBL28200688 | 0.75 | ALDH1A1 (0.42) | ALDH1A1RAB9ANPC1HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4036100-A1 | SPIROKETAL DERIVATIVES AND PROCESS FOR PREPARATION OF SPIROKETAL DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2022-08-03 | — | — | EP | disclosed |
| EP-3170834-B1 | CRYSTALLINE FORMS OF (1S,3'R,4'S,5'S,6'R)-6-[(4-ETHYLPHENYL)METHYL]-3',4',5',6'-TETRAHYDRO-6'-(HYDROXYMETHYL)SPIRO[ISOBENZOFURAN-1(3H) 2'-[2H]PYRAN]-3',4',5'-TRIOL | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2022-02-09 | — | — | EP | disclosed |
| EP-3170834-A1 | CRYSTALLINE FORMS OF (1S,3'R,4'S,5'S,6'R)-6-[(4-ETHYLPHENYL)METHYL]-3',4',5',6'-TETRAHYDRO-6'- (HYDROXYMETHYL)SPIRO[ISOBENZOFURAN-1(3H) 2'-[2H]PYRAN]-3',4',5'-TRIOL | Chugai Seiyaku Kabushiki Kaisha (JP) | 2017-05-24 | — | — | EP | disclosed |
| EP-2308886-B1 | PROCESS FOR THE PRODUCTION OF A SPIROKETAL DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2016-12-07 | — | — | EP | disclosed |
| US-9163051-B2 | Crystal of spiroketal derivatives and process for preparation of spiroketal derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2015-10-20 | — | — | US | disclosed |
| US-20140024817-A1 | CRYSTAL OF SPIROKETAL DERIVATIVES AND PROCESS FOR PREPARATION OF SPIROKETAL DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2014-01-23 | — | — | US | disclosed |
| US-8569520-B2 | Crystal of spiroketal derivatives and process for preparation of spiroketal derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2013-10-29 | — | — | US | disclosed |
| US-20110306778-A1 | CRYSTAL OF SPIROKETAL DERIVATIVES AND PROCESS FOR PREPARATION OF SPIROKETAL DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-12-15 | — | — | US | disclosed |
| EP-2308886-A1 | CRYSTAL OF SPIROKETAL DERIVATIVE, AND PROCESS FOR PRODUCTION THEREOF | Chugai Seiyaku Kabushiki Kaisha (JP) | 2011-04-13 | — | — | EP | disclosed |
| EP-0955304-B1 | Bridged metallocene complexes for the (co)polymerization of olefins | POLIMERI EUROPA SPA (IT) | 2003-09-03 | — | — | EP | disclosed |
| US-6417418-B2 | SUCH AS 1,3-PROPENYLIDENE-(1-INDENYL)2 ZIRCONIUM DICHLORIDE; HIGH ACTIVITY, MAKES HIGH MOLECULAR WEIGHT POLYMERS | ENICHEM S.P.A. (IT) | 2002-07-09 | — | — | US | disclosed |
| US-20010031885-A1 | Bridged metallocene complex for the (co) polymerization of olefins | ENICHEM S.P.A. (IT) | 2001-10-18 | — | — | US | disclosed |
| US-6211110-B1 | Bridged metallocene complex for the (co)polymerization of olefins | ENICHEM S.P.A. (IT) | 2001-04-03 | — | — | US | disclosed |
| EP-0955304-A2 | Bridged metallocene complex for the (co)polymerization of olefins | Enichem S.p.A. (IT) | 1999-11-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306778-A1 | CRYSTAL OF SPIROKETAL DERIVATIVES AND PROCESS FOR PREPARATION OF SPIROKETAL DERIVATIVES | KLK6, WNK1, WNK3 | IDO1 3360/4885TAAR1 1651/4885ALDH1A1 599/4885 |
| US-20140024817-A1 | CRYSTAL OF SPIROKETAL DERIVATIVES AND PROCESS FOR PREPARATION OF SPIROKETAL DERIVATIVES | KLK6, WNK1, WNK3 | IDO1 3360/4885TAAR1 1651/4885ALDH1A1 599/4885 |
| US-20010031885-A1 | Bridged metallocene complex for the (co) polymerization of olefins | POF1B, MACF1, HAO2 | IDO1 2635/4885TAAR1 2334/4885ALDH1A1 2395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.