Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630748 | 0.92 | NPC1 (0.56) | NPC1RAB9AALDH1A1MAPK1NUDT1 | |
| SCHEMBL2800474 | 0.89 | NPC1 (0.57) | NPC1RAB9AALDH1A1MAPK1NUDT1 | |
| SCHEMBL18134205 | 0.87 | NUDT1 (0.66) | NPC1RAB9AALDH1A1MAPK1NUDT1 | |
| SCHEMBL1576783 | 0.86 | SMN1; SMN2 (0.55) | NPC1RAB9AALDH1A1MAPK1NUDT1 | |
| SCHEMBL8446516 | 0.86 | NPC1 (0.54) | NPC1RAB9AALDH1A1MAPK1NUDT1 | |
| SCHEMBL8873887 | 0.85 | NPC1 (0.50) | NPC1RAB9AALDH1A1MAPK1NUDT1 | |
| SCHEMBL7464556 | 0.83 | ALDH1A1 (0.55) | NPC1RAB9AALDH1A1MAPK1NUDT1 | |
| SCHEMBL10618233 | 0.82 | NPC1 (0.51) | NPC1RAB9AALDH1A1MAPK1NUDT1 | |
| SCHEMBL1576921 | 0.82 | NPC1 (0.51) | NPC1RAB9AALDH1A1MAPK1NUDT1 | |
| SCHEMBL8874243 | 0.82 | RAB9A (0.48) | NPC1RAB9AALDH1A1MAPK1NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7304754-A | — | — | None | — | — | JP | disclosed |
| EP-3082751-B1 | TETRASUBSTITUTED PYRIMIDINE DERIVATIVES IN OXIDATIVE DYEING PREPARATIONS | HENKEL AG & CO KGAA (DE) | 2018-09-19 | — | — | EP | disclosed |
| EP-3205647-A2 | 2-(PYRIMIDIN-5-YL)-THIOPYRIMIDINE DERIVATIVES AS HSP70 AND HSC70 MODULATORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Memorial Sloan-Kettering Cancer Center (US) | 2017-08-16 | — | — | EP | disclosed |
| US-20170165265-A1 | HEAT SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING SAME | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2017-06-15 | — | — | US | disclosed |
| US-20170165265-A1 | HEAT SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING SAME | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2017-06-15 | — | — | US | disclosed |
| US-9636288-B2 | Means for oxidative dyeing of keratin fibers containing novel tetra-substituted derivatives of pyrimidine | HENKEL AG & CO. KGAA (DE) | 2017-05-02 | — | — | US | disclosed |
| US-9636288-B2 | Means for oxidative dyeing of keratin fibers containing novel tetra-substituted derivatives of pyrimidine | HENKEL AG & CO. KGAA (DE) | 2017-05-02 | — | — | US | disclosed |
| US-9567318-B2 | Substituted pyrimidine compounds and uses thereof | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2017-02-14 | — | — | US | disclosed |
| US-9567318-B2 | Substituted pyrimidine compounds and uses thereof | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2017-02-14 | — | — | US | disclosed |
| WO-2011022440-A9 | HEAT SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING SAME | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2016-11-10 | — | — | WO | disclosed |
| US-5580842-A | HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-03 | — | — | US | disclosed |
| US-5476936-A | Herbicides | BAYER AKTIENGESELLSCHAFT (DE) | 1995-12-19 | — | — | US | disclosed |
| JP-H07304754-A | 1-((2-(CYCLOPROPYLCARBONYL)-4-FLUOROPHENYL)SULFAMOYL)-3-(4,6-DIMETHOXY2-PYRIMIDINYL) UREA AND ITS HERBICIDAL USE | AMERICAN CYANAMID CO | 1995-11-21 | — | — | JP | disclosed |
| CN-1108656-A | N-azinyl-N'-(HET)arylsulphonyl-ureas | BAYER AG (DE) | 1995-09-20 | — | — | CN | disclosed |
| EP-0645386-A1 | N-Azinyl-N'-(het)arylsulfonylureas as herbicides | BAYER AG (DE) | 1995-03-29 | — | — | EP | disclosed |
| US-5157121-A | Reaction of alkyl(n-alkylsulfonyl-n-alkylamino)sulfonyl carbamates with 2-aminopyrimidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-10-20 | — | — | US | disclosed |
| EP-0279366-B1 | PROCESS FOR THE PREPARATION OF PYRIMIDINES | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-08-12 | — | — | EP | disclosed |
| EP-0467252-A2 | Process for the preparation of N-alkylsulfonylaminosulfonyl ureas | Hoechst Schering AgrEvo GmbH (DE) | 1992-01-22 | — | — | EP | disclosed |
| US-4960887-A | REACTING PROPANEDIIMIDATE WITH CARBONIC ACID IMINEDERIVATIVE | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-10-02 | — | — | US | disclosed |
| EP-0279366-A2 | Process for the preparation of pyrimidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-08-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170165265-A1 | HEAT SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING SAME | HSPBP1, HSF1, HSPA2 | NPC1 2801/4885RAB9A 4162/4885ALDH1A1 864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.