Sugi Predict

Sugi Predict / Compounds / Malonic Acid

Malonic Acid

Malonic Acid

SCHEMBL1576831

C=CC=C(c1ccccc1)c1ccccc1.O=C(O)CC(=O)O

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AKT1 P31749 1/20 0.45
▸ HPGD P15428 2/20 0.43
▸ CES1 P23141 2/20 0.43
▸ ALOX15 P16050 2/20 0.43
▸ MAPK1 P28482 2/20 0.43
▸ TDP1 Q9NUW8 2/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ CYP3A4 P08684 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ MTNR1A P48039 2/20 0.43
▸ MTNR1B P49286 2/20 0.43
▸ ALDH1A1 P00352 3/20 0.41
▸ LMNA P02545 1/20 0.41
▸ GAA P10253 1/20 0.39
▸ NR4A2 P43354 1/20 0.39
▸ HDAC3 O15379 2/20 0.39
▸ HDAC1 Q13547 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL57798 0.85 AKT1 (0.46) AKT1CES1MAPK1TDP1CYP3A4
SCHEMBL10555014 0.83 AKT1 (0.44) AKT1CES1MAPK1TDP1MTNR1A
SCHEMBL11442993 0.83 AKT1 (0.44) AKT1HPGDCES1ALOX15MAPK1
SCHEMBL7935762 0.83 AKT1 (0.44) AKT1CES1MAPK1TDP1MTNR1A
SCHEMBL11472197 0.82 TSHR (0.56) AKT1CES1ALOX15ALDH1A1DAO
SCHEMBL11472193 0.82 TSHR (0.56) AKT1CES1ALOX15ALDH1A1DAO
Alcohol SCHEMBL9291969 0.80 AKT1 (0.39) AKT1CES1TDP1MAPTMTNR1A
(Z)-1,2-Diphenylethene SCHEMBL9544908 0.76 MAOB (0.44) AKT1MEN1MAPTKMT2ASMN1; SMN2
(Z)-1,2-Diphenylethene SCHEMBL9544912 0.76 MAOB (0.44) AKT1MEN1MAPTKMT2ASMN1; SMN2
SCHEMBL9520971 0.76 MTNR1A (0.50) HPGDCES1ALOX15MAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024054923-A2 SUNSCREEN COMPOSITIONS AND METHODS OF USE MARY KAY INC. (US) 2024-03-14 — — WO claimed
EP-3793512-B1 METHODS FOR BOOSTING UVA PHOTO-PROTECTION USING ANTIOXIDANTS OREAL (FR) 2024-02-21 — — EP claimed
CN-116546962-A Skin care composition 莱雅公司 2023-08-04 — — CN claimed
US-11583480-B2 Sunscreen composition with a high UV filter load L'OREAL (FR) 2023-02-21 — — US claimed
US-20220387271-A1 MINERAL SUNSCREEN COMPOSITIONS L'OREAL (FR) 2022-12-08 — — US claimed
WO-2022110175-A1 COMPOSITIONS FOR SKIN CARE L'OREAL (FR) 2022-06-02 — — WO claimed
CN-109689012-B Photostable compositions and methods of use 莱雅公司 2022-05-31 — — CN claimed
EP-3880159-A1 MINERAL SUNSCREEN COMPOSITIONS L'Oréal (FR) 2021-09-22 — — EP claimed
CN-113164335-A Mineral sunscreen compositions 欧莱雅 2021-07-23 — — CN claimed
US-20210186848-A1 WATER RESISTANCE SUNSCREEN COMPOSITIONS L'OREAL (FR) 2021-06-24 — — US claimed
EP-2501359-A1 A COSMETIC OR DERMATOLOGICAL COMPOSITION WITH LOW STICKINESS, CONTAINING A LIPOPHILIC ACTIVE INGREDIENT L'Oréal (FR) 2012-09-26 — — EP claimed
WO-2012119861-A2 USE OF A 2-METHYLSUCCINIC ACID DIESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS CONTAINING THE SAME L'OREAL (FR) 2012-09-13 — — WO claimed
EP-2482793-A1 USE OF PIPERIDINE ESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT L'Oréal (FR) 2012-08-08 — — EP claimed
EP-2482791-A1 USE OF CAPROLACTAM DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT L'Oréal (FR) 2012-08-08 — — EP claimed
WO-2011061864-A1 A COSMETIC OR DERMATOLOGICAL COMPOSITION WITH LOW STICKINESS, CONTAINING A LIPOPHILIC ACTIVE INGREDIENT L'OREAL (FR) 2011-05-26 — — WO claimed
WO-2011038778-A1 USE OF CAPROLACTAM DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT L'OREAL (FR) 2011-04-07 — — WO claimed
WO-2011038776-A1 USE OF PIPERIDINE ESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT L'OREAL (FR) 2011-04-07 — — WO claimed
EP-2266531-A1 Cosmetic composition comprising a superabsorbent polymer and an organic UV filter L'Oréal (FR) 2010-12-29 — — EP claimed
US-20100143276-A1 Ester solvents derived from 4-carboxy-2-pyrrolidinone formulated into UV-screening cosmetic compositions L'OREAL (FR) 2010-06-10 — — US claimed
EP-2193783-A1 Use of an ester derived from 4-carboxy-2-pyrrolidinone as a solvent in cosmetic compositions; cosmetic compositions containing same L'Oreal (FR) 2010-06-09 — — EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210186848-A1 WATER RESISTANCE SUNSCREEN COMPOSITIONS CUTA, DSG1, ERCC1 AKT1 2495/4885HPGD 513/4885CES1 1409/4885
US-20220387271-A1 MINERAL SUNSCREEN COMPOSITIONS POLB, POLK, XRCC6 AKT1 2255/4885HPGD 748/4885CES1 3658/4885
US-11583480-B2 Sunscreen composition with a high UV filter load RAD50, OGG1, UNG AKT1 3880/4885HPGD 407/4885CES1 2828/4885
US-20100143276-A1 Ester solvents derived from 4-carboxy-2-pyrrolidinone formulated into UV-screening cosmetic compositions FASN, ALOX12, PAH AKT1 891/4885HPGD 424/4885CES1 16/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.