Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | EIF4E | P06730 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775543 | 0.90 | LMNA (0.45) | LMNAMAPTNPSR1EIF4EPOLB | |
| SCHEMBL15775590 | 0.84 | NPC1 (0.49) | LMNAMAPTEIF4EABCG2POLB | |
| SCHEMBL15775156 | 0.83 | NR1I3 (0.48) | LMNAMAPTNPSR1EIF4EPOLB | |
| SCHEMBL15776164 | 0.81 | SQOR (0.47) | LMNAMAPTNPSR1EIF4EABCG2 | |
| SCHEMBL15775546 | 0.80 | XDH (0.47) | NPSR1ABCG2XDHSMN1; SMN2KDM4E | |
| SCHEMBL15775231 | 0.80 | SQOR (0.43) | MAPTEIF4EABCG2POLBXDH | |
| SCHEMBL15775175 | 0.80 | EIF4E (0.43) | LMNAMAPTNPSR1EIF4EABCG2 | |
| SCHEMBL15775280 | 0.79 | ELANE (0.43) | LMNAMAPTNPSR1EIF4EABCG2 | |
| SCHEMBL15775312 | 0.76 | SQOR (0.44) | MAPTEIF4EABCG2POLBKDM4E | |
| SCHEMBL15775322 | 0.75 | TDP1 (0.41) | LMNAMAPTPOLBSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |