Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.39 |
| ▸ | PDCD1LG2 | Q9BQ51 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775449 | 1.00 | L3MBTL1 (0.48) | L3MBTL1ABL1HSP90AA1HSP90AB1NR4A2 | |
| SCHEMBL15775195 | 0.86 | HSP90AA1 (0.47) | L3MBTL1HSP90AA1HSP90AB1NR4A2CD274 | |
| SCHEMBL15775105 | 0.85 | SQOR (0.53) | HSP90AA1HSP90AB1TACR3ALDH1A1CYP3A4 | |
| SCHEMBL15775490 | 0.81 | ACP1 (0.46) | CYP3A4TSHRHSD17B10TRPM8SQOR | |
| SCHEMBL15775580 | 0.79 | ALDH1A1 (0.46) | L3MBTL1ABL1TACR3ALDH1A1HPGD | |
| SCHEMBL15775605 | 0.78 | NR1I3 (0.53) | TACR3NR1I3SQOR | |
| SCHEMBL15775748 | 0.75 | SQOR (0.53) | ALDH1A1HPGDHSD17B10SQOR | |
| SCHEMBL15775799 | 0.74 | SQOR (0.54) | ALDH1A1NR1I3CYP3A4HPGDTSHR | |
| SCHEMBL15775389 | 0.74 | ESR1 (0.45) | TACR3ALDH1A1CYP3A4HPGDHSD17B10 | |
| SCHEMBL2446620 | 0.73 | L3MBTL1 (0.45) | L3MBTL1ABL1HSP90AA1HSP90AB1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |