Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | EIF4E | P06730 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775590 | 0.90 | NPC1 (0.49) | NPC1CASP3RAB9ASENP7FBP1 | |
| SCHEMBL15775156 | 0.77 | NR1I3 (0.48) | PIN1MAPTEIF4EMEN1KMT2A | |
| SCHEMBL15775231 | 0.75 | SQOR (0.43) | NPC1CASP3RAB9ASENP7MAPT | |
| SCHEMBL15775417 | 0.75 | LMNA (0.45) | MAPTGAAEIF4ESMN1; SMN2KDM4E | |
| SCHEMBL15776164 | 0.74 | SQOR (0.47) | MAPTGAAEIF4EABCG2LMNA | |
| SCHEMBL15775280 | 0.74 | ELANE (0.43) | MAPTEIF4ESMN1; SMN2KDM4EMEN1 | |
| SCHEMBL15775543 | 0.71 | LMNA (0.45) | MAPTEIF4ESMN1; SMN2KDM4EMEN1 | |
| SCHEMBL15775312 | 0.71 | SQOR (0.44) | NPC1MAPTGAAEIF4EKDM4E | |
| SCHEMBL15775322 | 0.70 | TDP1 (0.41) | PIN1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL15775364 | 0.69 | ALDH1A1 (0.49) | PIN1MAPTEIF4EABCG2SQOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |