Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL714357 | 0.98 | TSHR (0.39) | TSHRKDM4ETDP1USP2MAPT | |
| SCHEMBL712408 | 0.98 | TSHR (0.39) | TSHRKDM4ETDP1USP2MAPT | |
| SCHEMBL403954 | 0.98 | TSHR (0.39) | TSHRKDM4ETDP1USP2MAPT | |
| SCHEMBL713038 | 0.98 | TSHR (0.39) | TSHRKDM4ETDP1USP2MAPT | |
| SCHEMBL720226 | 0.98 | TSHR (0.39) | TSHRKDM4ETDP1USP2MAPT | |
| SCHEMBL715364 | 0.98 | TSHR (0.39) | TSHRKDM4ETDP1USP2MAPT | |
| SCHEMBL716379 | 0.98 | TSHR (0.39) | TSHRKDM4ETDP1USP2MAPT | |
| SCHEMBL715943 | 0.98 | TSHR (0.39) | TSHRKDM4ETDP1USP2MAPT | |
| SCHEMBL713217 | 0.98 | TSHR (0.39) | TSHRKDM4ETDP1USP2MAPT | |
| Ammonia Solution, Strong SCHEMBL4160630 | 0.96 | TSHR (0.38) | TSHRKDM4ETDP1USP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101407-B1 | KIT AND METHOD FOR ELECTRON MICROSCOPE OBSERVATION | JAPAN SCIENCE & TECH AGENCY (JP) | 2023-03-08 | — | — | EP | disclosed |
| US-10128078-B2 | Protective agent for electron microscopic observation of biological sample in water-containing state, kit for electron microscopic observation, methods for observation, diagnosis, evaluation, and quantification by electron microscope, and sample stage | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2018-11-13 | — | — | US | disclosed |
| EP-2894185-B1 | ORGANIC POLYMER THIN FILM, AND METHOD FOR PRODUCING SAME | JAPAN SCIENCE & TECH AGENCY (JP) | 2017-11-29 | — | — | EP | disclosed |
| US-20170282130-A1 | ORGANIC POLYMER THIN MEMBRANE, AND METHOD FOR PRODUCING SAME | JAPAN SCIENCE & TECH AGENCY (JP) | 2017-10-05 | — | — | US | disclosed |
| US-9687793-B2 | Organic polymer thin membrane, and method for producing same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2017-06-27 | — | — | US | disclosed |
| EP-2755225-B1 | ELECTRON-MICROSCOPIC EXAMINATION METHOD FOR EXAMINING A LIVING BIOLOGICAL SAMPLE | JAPAN SCIENCE & TECH AGENCY (JP) | 2017-05-10 | — | — | EP | disclosed |
| US-9557253-B2 | Electron microscopic observation method for observing biological sample in shape as it is, and composition for evaporation suppression under vacuum, scanning electron microscope, and transmission electron microscope used in the method | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2017-01-31 | — | — | US | disclosed |
| EP-3101407-A1 | PROTECTANT FOR ELECTRON MICROSCOPE OBSERVATION OF HYDRATED BIOLOGICAL SAMPLE, KIT FOR ELECTRON MICROSCOPE OBSERVATION, METHOD FOR OBSERVATION, DIAGNOSIS, EVALUATION, OR QUANTIFICATION BY ELECTRON MICROSCOPE, AND SAMPLE STAGE | Japan Science And Technology Agency (JP) | 2016-12-07 | — | — | EP | disclosed |
| US-20160343539-A1 | PROTECTIVE AGENT FOR ELECTRON MICROSCOPIC OBSERVATION OF BIOLOGICAL SAMPLE IN WATER-CONTAINING STATE, KIT FOR ELECTRON MICROSCOPIC OBSERVATION, METHODS FOR OBSERVATION, DIAGNOSIS, EVALUATION, AND QUANTIFICATION BY ELECTRON MICROSCOPE, AND SAMPLE STAGE | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2016-11-24 | — | — | US | disclosed |
| US-20150224452-A1 | ORGANIC POLYMER THIN MEMBRANE, AND METHOD FOR PRODUCING SAME | Japan Science and Technology Agency of Saitama | 2015-08-13 | — | — | US | disclosed |
| EP-2894185-A1 | ORGANIC POLYMER THIN FILM, AND METHOD FOR PRODUCING SAME | Japan Science and Technology Agency (JP) | 2015-07-15 | — | — | EP | disclosed |
| US-20140227734-A1 | ELECTRON MICROSCOPIC OBSERVATION METHOD FOR OBSERVING BIOLOGICAL SAMPLE IN SHAPE AS IT IS, AND COMPOSITION FOR EVAPORATION SUPPRESSION UNDER VACUUM, SCANNING ELECTRON MICROSCOPE, AND TRANSMISSION ELECTRON MICROSCOPE USED IN THE METHOD | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2014-08-14 | — | — | US | disclosed |