Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 2/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL957751 | 0.79 | LMNA (0.48) | PTGER4PTGER2LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL2610329 | 0.77 | GPR52 (0.42) | FABP4LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14785546 | 0.75 | PTGER1 (0.49) | FABP4ALDH1A1MAPTMAPK1KMT2A | |
| SCHEMBL14785493 | 0.74 | ALDH1A1 (0.40) | HTTALDH1A1MAPTKMT2A | |
| SCHEMBL2998761 | 0.73 | DHPS (0.62) | LMNASMN1; SMN2L3MBTL1NCOA3HTT | |
| SCHEMBL11345303 | 0.70 | HTR6 (0.52) | L3MBTL1AKR1B1KMT2ACYP2C19HTR6 | |
| SCHEMBL27982172 | 0.69 | ALDH1A1 (0.43) | L3MBTL1ALDH1A1TDP1 | |
| SCHEMBL8042876 | 0.69 | ALDH1A1 (0.44) | LMNASMN1; SMN2L3MBTL1NCOA3HTT | |
| SCHEMBL6695776 | 0.68 | FABP4 (1.00) | FABP4 | |
| SCHEMBL28801601 | 0.67 | ALDH1A1 (0.61) | LMNASMN1; SMN2L3MBTL1NCOA3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |