SCHEMBL16049041

SCHEMBL16049041

Clc1ccc(-n2c(-c3cnc(N4CCOCC4)nc3)nc3ccncc32)nc1

nearest known ligand 0.80

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ AOC3 Q16853 18/20 0.80
▸ KCNH2 Q12809 3/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16053370 0.91 KCNH2 (0.83) AOC3KCNH2
SCHEMBL16053357 0.89 AOC3 (0.81) AOC3KCNH2
SCHEMBL16047409 0.89 AOC3 (1.00) AOC3KCNH2
SCHEMBL30025643 0.88 KCNH2 (1.00) AOC3KCNH2
SCHEMBL16049446 0.88 KCNH2 (1.00) AOC3KCNH2
SCHEMBL20913192 0.87 KCNH2 (0.73) AOC3KCNH2
SCHEMBL16052898 0.82 AOC3 (1.00) AOC3KCNH2
SCHEMBL17336342 0.82 AOC3 (0.82) AOC3KCNH2
SCHEMBL16048114 0.82 KCNH2 (1.00) AOC3KCNH2
SCHEMBL30026427 0.82 KCNH2 (1.00) AOC3KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10968223-B2 Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors PROXIMAGEN, LLC (US) 2021-04-06 — — US claimed
US-20200347059-A1 IMIDAZO[4,5-C]PYRIDINE AND PYRROLO[2,3-C]PYRIDINE DERIVATIVES AS SSAO INHIBITORS PROXIMAGEN, LLC (US) 2020-11-05 — — US claimed
US-20200147059-A1 NEW THERAPEUTIC USES OF ENZYME INHIBITORS PROXIMAGEN, LLC (US) 2020-05-14 — — US claimed
CN-111032029-A Vascular adhesion protein-1 inhibitors for the prevention or treatment of migraine 普罗克斯马根有限责任公司 2020-04-17 — — CN claimed
US-10428066-B2 Imidazo[4,5-C]pyridine and pyrrolo[2,3-C]pyridine derivatives as SSAO inhibitors PROXIMAGEN, LLC (US) 2019-10-01 — — US claimed
EP-2970260-B1 IMIDAZO[4,5-C]PYRIDINE AND PYRROLO[2,3-C]PYRIDINE DERIVATIVES AS SSAO INHIBITORS PROXIMAGEN LLC (US) 2019-04-24 — — EP claimed
EP-2970260-A1 IMIDAZO[4,5-C]PYRIDINE AND PYRROLO[2,3-C]PYRIDINE DERIVATIVES AS SSAO INHIBITORS Proximagen Limited (GB) 2016-01-20 — — EP claimed
WO-2014140592-A1 IMIDAZO[4,5-C]PYRIDINE AND PYRROLO[2,3-C]PYRIDINE DERIVATIVES AS SSAO INHIBITORS PROXIMAGEN LIMITED (GB) 2014-09-18 — — WO claimed
US-20230110165-A1 Substituted Imidazo[4,5-c]pyridine Compounds and Compositions Thereof PROXIMAGEN LLC (US) 2023-04-13 — — US disclosed
US-11512082-B2 Substituted imidazo[4,5-c]pyridine compounds and compositions thereof PROXIMAGEN, LLC (US) 2022-11-29 — — US disclosed
US-10968223-B2 Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors PROXIMAGEN, LLC (US) 2021-04-06 — — US disclosed
US-10968223-B2 Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors PROXIMAGEN, LLC (US) 2021-04-06 — — US disclosed
EP-3777846-A1 VAP-1 INHIBITORS FOR TREATING PAIN BenevolentAI Cambridge Limited (GB) 2021-02-17 — — EP disclosed
EP-3777846-A1 VAP-1 INHIBITORS FOR TREATING PAIN BenevolentAI Cambridge Limited (GB) 2021-02-17 — — EP disclosed
US-20150258101-A1 NEW COMPOUNDS PROXIMAGEN LIMITED (GB) 2015-09-17 — — US disclosed
WO-2014140592-A1 IMIDAZO[4,5-C]PYRIDINE AND PYRROLO[2,3-C]PYRIDINE DERIVATIVES AS SSAO INHIBITORS PROXIMAGEN LIMITED (GB) 2014-09-18 — — WO disclosed
US-20140275040-A1 NEW COMPOUNDS PROXIMAGEN LIMITED (GB) 2014-09-18 — — US disclosed
US-20140275040-A1 NEW COMPOUNDS PROXIMAGEN LIMITED (GB) 2014-09-18 — — US disclosed
US-20140275040-A1 NEW COMPOUNDS PROXIMAGEN LIMITED (GB) 2014-09-18 — — US disclosed
US-8680062-B2 System for delivering therapeutic agents into living cells and cells nuclei Deliversir Ltd. (IL) 2014-03-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11512082-B2 Substituted imidazo[4,5-c]pyridine compounds and compositions thereof PNPO, XDH, EPX AOC3 12/4885KCNH2 315/4885
US-10428066-B2 Imidazo[4,5-C]pyridine and pyrrolo[2,3-C]pyridine derivatives as SSAO inhibitors PNPO, SSB, XDH AOC3 10/4885KCNH2 364/4885
US-20140275040-A1 NEW COMPOUNDS SSB, ALOX15B, ALOX12 AOC3 133/4885KCNH2 4546/4885
US-10968223-B2 Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors PNPO, PPOX, SCO2 AOC3 7/4885KCNH2 448/4885
US-20230110165-A1 Substituted Imidazo[4,5-c]pyridine Compounds and Compositions Thereof PNPO, XDH, EPX AOC3 12/4885KCNH2 315/4885
US-20200347059-A1 IMIDAZO[4,5-C]PYRIDINE AND PYRROLO[2,3-C]PYRIDINE DERIVATIVES AS SSAO INHIBITORS PNPO, PPOX, SCO2 AOC3 7/4885KCNH2 448/4885
US-20200147059-A1 NEW THERAPEUTIC USES OF ENZYME INHIBITORS VAPB, VAPA, SMOX AOC3 4/4885KCNH2 1505/4885
US-20150258101-A1 NEW COMPOUNDS AOX1, QSOX1, MAOB AOC3 85/4885KCNH2 2492/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback