Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.45 |
| ▸ | WNT1 | P04628 | 6/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.44 |
| ▸ | SELE | P16581 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | LDLR | P01130 | 1/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16197797 | 0.79 | PORCN (0.68) | MEN1LMNATP53MAPTKMT2A | |
| SCHEMBL24465876 | 0.76 | MAPT (0.51) | GSK3BDYRK1AICAM1SELEHPGDS | |
| SCHEMBL21978557 | 0.75 | HPGDS (0.52) | HPGDSLDLRPCSK9MEN1LMNA | |
| SCHEMBL2955123 | 0.75 | HPGD (0.50) | MAPTSMN1; SMN2 | |
| SCHEMBL5344758 | 0.73 | HPGDS (0.53) | GSK3BDYRK1AWNT1MMP2MMP13 | |
| SCHEMBL5779858 | 0.73 | SMN1; SMN2 (0.55) | GSK3BDYRK1AWNT1IDO1MEN1 | |
| SCHEMBL10985317 | 0.72 | IDO1 (0.53) | GSK3BDYRK1AWNT1MMP2MMP13 | |
| SCHEMBL19981228 | 0.72 | ATP1A1 (0.45) | GSK3BDYRK1AHPGDSLDLRPCSK9 | |
| SCHEMBL7733929 | 0.71 | MAPT (0.66) | LMNAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL9827591 | 0.70 | AOC3 (0.42) | LMNAMAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014175832-A1 | WNT PATHWAY MODULATORS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-10-30 | — | — | WO | disclosed |