Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 5/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.46 |
| ▸ | WNT1 | P04628 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | CLK3 | P49761 | 1/20 | 0.45 |
| ▸ | LDLR | P01130 | 1/20 | 0.45 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | ADH5 | P11766 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821311 | 0.84 | ADH5 (0.54) | HPGDSGSK3BDYRK1AWNT1CLK2 | |
| SCHEMBL5351176 | 0.82 | GSK3B (0.49) | HPGDSGPR119GSK3BDYRK1AWNT1 | |
| SCHEMBL17728960 | 0.81 | IDO1 (0.59) | HPGDSGSK3BDYRK1ALDLRPCSK9 | |
| SCHEMBL12263261 | 0.80 | HPGD (0.44) | CHEK1IDO1MKNK1MKNK2ADH5 | |
| SCHEMBL28540060 | 0.79 | HTR7 (0.46) | IDO1MKNK1MKNK2SRCADH5 | |
| SCHEMBL10985317 | 0.78 | IDO1 (0.53) | HPGDSGPR119GSK3BDYRK1AWNT1 | |
| SCHEMBL1502339 | 0.76 | IDO1 (0.51) | HPGDSGPR119GSK3BDYRK1ACHEK1 | |
| SCHEMBL5779858 | 0.76 | SMN1; SMN2 (0.55) | GSK3BDYRK1AWNT1IDO1CYP3A4 | |
| SCHEMBL21857535 | 0.75 | KMT2A (0.56) | HPGDSGSK3BDYRK1AWNT1IDO1 | |
| SCHEMBL28531484 | 0.75 | IDO1 (0.47) | HPGDSGPR119GSK3BDYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892888-B1 | N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2018-04-18 | — | — | EP | disclosed |
| US-9469631-B2 | N-cyclopropyl-N-piperidinyl-amides, pharmaceutical compositions containing them, and uses thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-10-18 | — | — | US | disclosed |
| US-20150225390-A1 | N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
| EP-2892888-A1 | N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014037327-A1 | N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-03-13 | — | — | WO | disclosed |
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2010-07-29 | — | — | US | disclosed |
| US-7300934-B2 | Benzamide nitriles | ROCHE PALO ALTO LLC (US) | 2007-11-27 | — | — | US | disclosed |
| US-7300934-B2 | Benzamide nitriles | ROCHE PALO ALTO LLC (US) | 2007-11-27 | — | — | US | disclosed |
| US-7300934-B2 | Benzamide nitriles | ROCHE PALO ALTO LLC (US) | 2007-11-27 | — | — | US | disclosed |
| EP-1633701-A1 | BENZAMIDE NITRILE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004106285-A1 | BENZAMIDE NITRILE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-12-09 | — | — | WO | disclosed |
| WO-2004106285-A1 | BENZAMIDE NITRILE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-12-09 | — | — | WO | disclosed |
| US-20040248949-A1 | Benzamide nitriles | ROCHE PALO ALTO LLC | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225390-A1 | N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USES THEREOF | GPR18, GPR39, GPR4 | HPGDS 436/4885GPR119 7/4885GSK3B 4325/4885 |
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, ABCB11 | HPGDS 205/4885GPR119 2110/4885GSK3B 3045/4885 |
| US-20040248949-A1 | Benzamide nitriles | CTSK, CTSS, CMA1 | HPGDS 3367/4885GPR119 1447/4885GSK3B 4679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.