SCHEMBL16202014

SCHEMBL16202014

Cc1cccc(-n2cnc(C)n2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.45
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
HSP90AA1 P07900 1/20 0.42
MGLL Q99685 1/20 0.42
RXRA P19793 5/20 0.41
GRIN1 Q05586 5/20 0.41
GRIN2B Q13224 5/20 0.41
ADORA3 P0DMS8 3/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
ADORA1 P30542 2/20 0.40
ADORA2A P29274 1/20 0.40
CYP11B1 P15538 1/20 0.40
CYP11B2 P19099 1/20 0.40
ADRB1 P08588 1/20 0.40
ACHE P22303 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
TP53 P04637 1/20 0.38
MAPT P10636 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18291888 0.82 ALDH1A1 (0.42) ALDH1A1MEN1KMT2AHSP90AA1MGLL
SCHEMBL27294667 0.82 ALDH1A1 (0.42) ALDH1A1MEN1KMT2AHSP90AA1MGLL
SCHEMBL21863282 0.82 KEAP1 (0.47) KMT2AMGLLRXRAGRIN1GRIN2B
SCHEMBL7127572 0.82 MAPT (0.49) ALDH1A1MEN1KMT2ATP53MAPT
SCHEMBL16202012 0.82 NOTUM (0.47) ALDH1A1MEN1KMT2AMGLLL3MBTL1
SCHEMBL10361072 0.82 MEN1 (0.46) ALDH1A1MEN1KMT2AHSP90AA1MGLL
SCHEMBL30186345 0.82 FGFR1 (0.44) ALDH1A1MEN1KMT2AACHETP53
SCHEMBL16202016 0.81 MAPK8 (0.42) ALDH1A1MEN1KMT2AHSP90AA1MGLL
SCHEMBL21863285 0.81 NOTUM (0.51) ALDH1A1MGLLADORA3ADORA1ADORA2A
SCHEMBL7044640 0.80 HPGD (0.49) ALDH1A1MEN1KMT2AL3MBTL1ADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240018151-A1 NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME TME THERAPEUTICS LLC 2024-01-18 US disclosed
WO-2022086993-A1 NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME TME THERAPEUTICS LLC (US) 2022-04-28 WO disclosed
WO-2020065613-A1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2020-04-02 WO disclosed
US-20160249615-A1 Use of Strobilurin Type Compounds for Combating Phytopathogenic Fungi Resistant to QO Inhibitors BASF SE (DE) 2016-09-01 US disclosed
US-20160145219-A1 STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2016-05-26 US disclosed
US-20160145202-A1 Strobilurin Type Compounds for Combating Phytopathogenic Fungi BASF SE (DE) 2016-05-26 US disclosed
US-20160122327-A1 STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2016-05-05 US disclosed
US-9271501-B2 Use of strobilurin type compounds for combating phytopathogenic fungi resistant to QO inhibitors BASF SE (DE) 2016-03-01 US disclosed
US-20140323305-A1 Use of Strobilurin Type Compounds for Combating Phytopathogenic Fungi Resistant to QO Inhibitors BASF SE (DE) 2014-10-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160122327-A1 STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI SNX1, DPM1, SNU13 ALDH1A1 2106/4885MEN1 2118/4885KMT2A 3783/4885
US-20160145219-A1 STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI DPM1, CROCC, SNX1 ALDH1A1 3309/4885MEN1 3302/4885KMT2A 3043/4885
US-20160145202-A1 Strobilurin Type Compounds for Combating Phytopathogenic Fungi DPM1, CROCC, SNX1 ALDH1A1 3309/4885MEN1 3302/4885KMT2A 3043/4885
US-20140323305-A1 Use of Strobilurin Type Compounds for Combating Phytopathogenic Fungi Resistant to QO Inhibitors SQOR, COX5B, UQCRB ALDH1A1 2278/4885MEN1 2720/4885KMT2A 3197/4885
US-20240018151-A1 NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME PIKFYVE, PIK3CD, PIK3R5 ALDH1A1 4878/4885MEN1 3336/4885KMT2A 4126/4885
US-20160249615-A1 Use of Strobilurin Type Compounds for Combating Phytopathogenic Fungi Resistant to QO Inhibitors SQOR, COX5B, UQCRB ALDH1A1 2278/4885MEN1 2720/4885KMT2A 3197/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.