Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.44 |
| ▸ | RAB9A | P51151 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | PKM | P14618 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15445593 | 0.89 | MAOA (0.41) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL20144337 | 0.83 | NPBWR1 (0.44) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL15442436 | 0.80 | MAOA (0.43) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL15442444 | 0.70 | NR2E1 (0.49) | SMN1; SMN2MAOAMAOBNR2E1TP53 | |
| SCHEMBL29848567 | 0.69 | NR2E1 (0.61) | NR2E1FLT3 | |
| SCHEMBL9701793 | 0.68 | NR2E1 (0.48) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13528291 | 0.67 | SMN1; SMN2 (0.57) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1551571 | 0.66 | ALDH1A1 (0.58) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3343040 | 0.66 | NR2E1 (0.48) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL16283149 | 0.65 | MAPK13 (0.44) | MAPTGAANR2E1MAPK1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174996-B2 | Protein kinase inhibitors | ASTAR BIOTECH LLC (US) | 2015-11-03 | — | — | US | disclosed |
| US-9174996-B2 | Protein kinase inhibitors | ASTAR BIOTECH LLC (US) | 2015-11-03 | — | — | US | disclosed |
| US-20140364436-A1 | Protein Kinase Inhibitors | ASTAR BIOTECH LLC (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140364436-A1 | Protein Kinase Inhibitors | ASTAR BIOTECH LLC (US) | 2014-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364436-A1 | Protein Kinase Inhibitors | MAP3K9, MAP3K6, MAP3K8 | NPC1 2554/4885RAB9A 894/4885KDM4E 783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.