Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15442436 | 0.91 | MAOA (0.43) | MAOAMAOBNPC1RAB9APKM | |
| SCHEMBL20144337 | 0.90 | NPBWR1 (0.44) | MAOAMAOBNPC1RAB9APKM | |
| SCHEMBL16283150 | 0.89 | NPC1 (0.44) | MAOAMAOBNPC1RAB9APKM | |
| SCHEMBL15443081 | 0.73 | ABL1 (0.51) | — | |
| SCHEMBL15445610 | 0.68 | HDAC3 (0.49) | — | |
| SCHEMBL29848567 | 0.67 | NR2E1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3343040 | 0.64 | NR2E1 (0.48) | MAOAMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22394099 | 0.64 | CYP1A2 (0.46) | MAOAMAOBPSEN1PSEN2APH1B | |
| SCHEMBL23049050 | 0.64 | NPBWR1 (0.42) | NPC1RAB9APKMSMN1; SMN2MAPT | |
| SCHEMBL27985278 | 0.64 | CYP1A2 (0.65) | MAOAMAOBNPC1RAB9APSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186247-B1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2021-03-03 | — | — | EP | disclosed |
| EP-2880038-B1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2018-05-16 | — | — | EP | disclosed |
| WO-2016029776-A1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2016-03-03 | — | — | WO | disclosed |
| US-9174996-B2 | Protein kinase inhibitors | ASTAR BIOTECH LLC (US) | 2015-11-03 | — | — | US | disclosed |
| US-9174996-B2 | Protein kinase inhibitors | ASTAR BIOTECH LLC (US) | 2015-11-03 | — | — | US | disclosed |
| US-20140364436-A1 | Protein Kinase Inhibitors | ASTAR BIOTECH LLC (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140364436-A1 | Protein Kinase Inhibitors | ASTAR BIOTECH LLC (US) | 2014-12-11 | — | — | US | disclosed |
| US-8859553-B2 | Protein kinase inhibitors | ASTAR BIOTECH LLC (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859553-B2 | Protein kinase inhibitors | ASTAR BIOTECH LLC (US) | 2014-10-14 | — | — | US | disclosed |
| WO-2014019338-A1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2014-02-06 | — | — | WO | disclosed |
| US-20140031354-A1 | Protein Kinase Inhibitors | ASTAR BIOTECH LLC (US) | 2014-01-30 | — | — | US | disclosed |
| US-20140031354-A1 | Protein Kinase Inhibitors | ASTAR BIOTECH LLC (US) | 2014-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364436-A1 | Protein Kinase Inhibitors | MAP3K9, MAP3K6, MAP3K8 | MAOA 4499/4885MAOB 4103/4885NPC1 2554/4885 |
| US-20140031354-A1 | Protein Kinase Inhibitors | MAP3K1, MAP3K5, MAP3K7 | MAOA 4362/4885MAOB 4212/4885NPC1 1544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.