SCHEMBL1628796

SCHEMBL1628796

Oc1ccccc1-n1nnc2c(Cc3cccc4c3nnn4-c3ccccc3O)cccc21

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KCNMA1 Q12791 3/20 0.58
▸ HSPA5 P11021 1/20 0.40
▸ KCNN4 O15554 1/20 0.34
▸ GAA P10253 2/20 0.33
▸ GFER P55789 1/20 0.33
▸ GRM2 Q14416 1/20 0.33
▸ DRD2 P14416 1/20 0.33
▸ DRD3 P35462 1/20 0.33
▸ IDO1 P14902 1/20 0.32
▸ CCNE1 P24864 1/20 0.32
▸ CDK2 P24941 1/20 0.32
▸ ATM Q13315 1/20 0.32
▸ ALDH1A1 P00352 3/20 0.31
▸ KDM4E B2RXH2 2/20 0.31
▸ LMNA P02545 2/20 0.31
▸ MAPT P10636 2/20 0.31
▸ HPGD P15428 2/20 0.31
▸ TSHR P16473 2/20 0.31
▸ HSD17B10 Q99714 2/20 0.31
▸ MEN1 O00255 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5183293 0.80 KCNMA1 (0.59) KCNMA1KCNN4GAAGFERGRM2
SCHEMBL7099276 0.75 CYP3A4 (0.41) KCNMA1GAADRD3ALDH1A1LMNA
SCHEMBL9777378 0.74 KCNMA1 (0.49) KCNMA1KCNN4GRM2ATMALDH1A1
SCHEMBL80393 0.74 KCNMA1 (1.00) KCNMA1GAAATMALDH1A1MAPT
SCHEMBL8445816 0.73 KCNMA1 (0.62) KCNMA1ATMALDH1A1LMNAMAPT
SCHEMBL8938828 0.72 KCNMA1 (0.47) KCNMA1KCNN4DRD2DRD3LMNA
SCHEMBL8764298 0.71 KCNMA1 (0.51) KCNMA1KCNN4GAAGFERIDO1
SCHEMBL2903449 0.69 KCNMA1 (0.45) KCNMA1GAAGFERIDO1ALDH1A1
SCHEMBL3969778 0.67 KCNMA1 (0.78) KCNMA1GAAATMALDH1A1KDM4E
SCHEMBL16311883 0.64 KCNMA1 (0.59) KCNMA1KCNN4GAAGFERIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2775993-B1 SOLID ANTI-SUN COMPOSITION BASED ON LIPOPHILIC ORGANIC UV SCREENING AGENT AND AEROGEL PARTICLES OF HYDROPHOBIC SILICA OREAL (FR) 2018-10-24 — — EP disclosed
US-9233056-B2 Solid anti-sun composition based on lipophilic organic UV screening agent and aerogel particles of hydrophobic silica L'OREAL (FR) 2016-01-12 — — US disclosed
US-9078820-B2 Oil-in-water emulsion containing an amphiphilic polymer and a silicone elastomer L'OREAL (FR) 2015-07-14 — — US disclosed
US-20140294975-A1 SOLID ANTI-SUN COMPOSITION BASED ON LIPOPHILIC ORGANIC UV SCREENING AGENT AND AEROGEL PARTICLES OF HYDROPHOBIC SILICA L'OREAL (FR) 2014-10-02 — — US disclosed
EP-2775993-A1 SOLID ANTI-SUN COMPOSITION BASED ON LIPOPHILIC ORGANIC UV SCREENING AGENT AND AEROGEL PARTICLES OF HYDROPHOBIC SILICA L'Oréal (FR) 2014-09-17 — — EP disclosed
WO-2013068236-A1 SOLID ANTI-SUN COMPOSITION BASED ON LIPOPHILIC ORGANIC UV SCREENING AGENT AND AEROGEL PARTICLES OF HYDROPHOBIC SILICA L'OREAL (FR) 2013-05-16 — — WO disclosed
US-20110088711-A1 WIPE WITH AN EMULSION CONTAINING A THICKENING POLYMER AND A HYDROPHOBIC MODIFIED INULIN L'OREAL (FR) 2011-04-21 — — US disclosed
US-20100221296-A1 OIL-IN-WATER EMULSION CONTAINING AN AMPHIPHILIC POLYMER AND A SILICONE ELASTOMER L'OREAL (FR) 2010-09-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110088711-A1 WIPE WITH AN EMULSION CONTAINING A THICKENING POLYMER AND A HYDROPHOBIC MODIFIED INULIN WIZ, CUTA, WAPL KCNMA1 4054/4885HSPA5 4019/4885KCNN4 3134/4885
US-20100221296-A1 OIL-IN-WATER EMULSION CONTAINING AN AMPHIPHILIC POLYMER AND A SILICONE ELASTOMER IDUA, PLOD3, ABHD16A KCNMA1 4710/4885HSPA5 370/4885KCNN4 4865/4885
US-20140294975-A1 SOLID ANTI-SUN COMPOSITION BASED ON LIPOPHILIC ORGANIC UV SCREENING AGENT AND AEROGEL PARTICLES OF HYDROPHOBIC SILICA CUTA, DSG1, KRT18 KCNMA1 1428/4885HSPA5 2195/4885KCNN4 2717/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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