Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | USP8 | P40818 | 2/20 | 0.31 |
| ▸ | USP7 | Q93009 | 2/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL535658 | 0.83 | ALDH1A1 (0.36) | KHKCSNK1A1CLK4KDM4EGAA | |
| SCHEMBL29439703 | 0.80 | HTT (0.35) | KHKCSNK1A1CLK4KDM4EGAA | |
| SCHEMBL21633090 | 0.80 | KDM4E (0.39) | TDP1KHKCSNK1A1CLK4KDM4E | |
| SCHEMBL16708968 | 0.80 | HTT (0.35) | KHKCSNK1A1CLK4KDM4EGAA | |
| SCHEMBL5177775 | 0.76 | KMT2A (0.33) | TDP1KDM4EKMT2A | |
| SCHEMBL24559177 | 0.76 | LMNA (0.34) | KHKKDM4EUSP8USP7 | |
| SCHEMBL1629508 | 0.76 | ALOX15 (0.35) | KHKKDM4EGAAADORA1ALOX15 | |
| SCHEMBL24559160 | 0.76 | KHK (0.31) | KHK | |
| SCHEMBL22715820 | 0.76 | NOTUM (0.35) | KHKKMT2A | |
| SCHEMBL24558933 | 0.76 | ALDH1A1 (0.38) | KHKKDM4EGAAUSP8USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523954-B1 | 1H-[1,2,3]TRIAZOLO[4,5-C]PYRIDINE-4- CARBONITRILE DERIVATIVES AS CATHEPSIN S INHIBITORS | MERCK SHARP & DOHME (NL) | 2014-04-16 | — | — | EP | disclosed |
| CN-101374838-B | 6-phenyl-1h-imidazo[4,5-c]pyridine-4-carbonitrile derivatives as cathepsin K and S inhibitors | ORGANON NV | 2013-04-03 | — | — | CN | disclosed |
| US-7932251-B2 | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives | N.V. ORGANON (NL) | 2011-04-26 | — | — | US | disclosed |
| US-7932251-B2 | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives | N.V. ORGANON (NL) | 2011-04-26 | — | — | US | disclosed |
| US-7932251-B2 | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives | N.V. ORGANON (NL) | 2011-04-26 | — | — | US | disclosed |
| EP-2178873-B1 | 6-PHENYL-1H-IMIDAZO[4,5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN INHIBITORS | ORGANON NV (NL) | 2010-12-22 | — | — | EP | disclosed |
| EP-2178873-B1 | 6-PHENYL-1H-IMIDAZO[4,5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN INHIBITORS | ORGANON NV (NL) | 2010-12-22 | — | — | EP | disclosed |
| CN-101842373-A | 6-phenyl-1H-imidazo [4,5-c] pyridine-4-6-carbonitrile derivatives as cathepsin inhibitors | ORGANON NV | 2010-09-22 | — | — | CN | disclosed |
| EP-2178873-A1 | 6-PHENYL-1H-IMIDAZO[4,5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN INHIBITORS | N.V. Organon (NL) | 2010-04-28 | — | — | EP | disclosed |
| EP-1979351-B1 | 6-PHENYL-1H-IMIDAZO[4, 5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN K AND S INHIBITORS | ORGANON NV (NL) | 2010-04-07 | — | — | EP | disclosed |
| US-20090099172-A1 | 6-PHENYL-1H-IMIDAZO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES | N. V. ORGANON | 2009-04-16 | — | — | US | disclosed |
| US-20090099172-A1 | 6-PHENYL-1H-IMIDAZO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES | N. V. ORGANON | 2009-04-16 | — | — | US | disclosed |
| US-20090099172-A1 | 6-PHENYL-1H-IMIDAZO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES | N. V. ORGANON | 2009-04-16 | — | — | US | disclosed |
| CN-101374838-A | 6-phenyl-1h-imidazo[4,5-c]pyridine-4-carbonitrile derivatives as cathepsin k and s inhibitors | ORGANON NV (NL) | 2009-02-25 | — | — | CN | disclosed |
| WO-2009010491-A1 | 6-PHENYL-1H-IMIDAZO[4,5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN INHIBITORS | N.V. ORGANON (NL) | 2009-01-22 | — | — | WO | disclosed |
| WO-2009010491-A1 | 6-PHENYL-1H-IMIDAZO[4,5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN INHIBITORS | N.V. ORGANON (NL) | 2009-01-22 | — | — | WO | disclosed |
| US-20070179138-A1 | 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives | N.V. ORGANON (NL) | 2007-08-02 | — | — | US | disclosed |
| US-20070179138-A1 | 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives | N.V. ORGANON (NL) | 2007-08-02 | — | — | US | disclosed |
| US-20070179138-A1 | 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives | N.V. ORGANON (NL) | 2007-08-02 | — | — | US | disclosed |
| WO-2007080191-A1 | 6-PHENYL-1H-IMIDAZO[4, 5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN K AND S INHIBITORS | N.V. ORGANON (NL) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099172-A1 | 6-PHENYL-1H-IMIDAZO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES | CTSS, CTSV, CTSB | TDP1 2953/4885KHK 2368/4885CSNK1A1 100/4885 |
| US-20070179138-A1 | 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives | CTSK, CTSS, CTSZ | TDP1 3068/4885KHK 452/4885CSNK1A1 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.