Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 4/20 | 0.41 |
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.40 |
| ▸ | MAOB known ✓ | P27338 | 2/20 | 0.40 |
| ▸ | DRD1 known ✓ | P21728 | 2/20 | 0.40 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 known ✓ | P21918 | 1/20 | 0.40 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL163037 | 0.95 | LMNA (0.47) | LMNATHRBTSHRPMP22HSD17B10 | |
| SCHEMBL162104 | 0.89 | DRD2 (0.48) | HTR1AHTR7DRD2MAOAMAOB | |
| Malonic Acid SCHEMBL161793 | 0.85 | OPRM1 (0.43) | OPRM1OPRK1DRD5PRCPMTNR1A | |
| Nitric Acid SCHEMBL161325 | 0.84 | DRD1 (0.41) | LMNAHTR1ADRD2OPRM1OPRK1 | |
| Glycolic Acid SCHEMBL158529 | 0.82 | KDM4E (0.41) | HTR1AHTR7DRD2OPRM1OPRK1 | |
| Adipic Acid SCHEMBL160638 | 0.80 | KDM4E (0.46) | HTR1AHTR7DRD2OPRM1OPRK1 | |
| Sulfuric Acid SCHEMBL174314 | 0.73 | DRD1 (0.65) | LMNATHRBTSHRPMP22HSD17B10 | |
| SCHEMBL11365140 | 0.72 | CES1 (0.48) | LMNATHRBTSHRPMP22HSD17B10 | |
| SCHEMBL158570 | 0.71 | HDAC1 (0.47) | LMNATHRBTSHRPMP22HSD17B10 | |
| SCHEMBL17662597 | 0.70 | DRD2 (0.55) | HTR1AHTR7DRD2ALDH1A1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611781-A1 | FAST-DISSOLVE DOSAGE FORMS OF 5-HT2C AGONISTS | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | claimed |
| WO-2012030951-A1 | FAST-DISSOLVE DOSAGE FORMS OF 5-HT2C AGONISTS | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | claimed |