Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.38 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15648793 | 0.81 | ALDH1A1 (0.62) | PLA2G2AALDH1A1L3MBTL1HPGDLMNA | |
| SCHEMBL12590494 | 0.74 | ALDH1A1 (0.47) | HPGDSALDH1A1HPGDLMNA | |
| SCHEMBL18856332 | 0.74 | RORC (0.43) | PLA2G2ARORCALDH1A1L3MBTL1TLR8 | |
| SCHEMBL6489036 | 0.73 | KMT2A (0.53) | ALDH1A1L3MBTL1HPGDLMNA | |
| SCHEMBL16462216 | 0.72 | RORC (0.55) | PLA2G2ARORCALDH1A1L3MBTL1TLR8 | |
| SCHEMBL18856329 | 0.72 | PLA2G2A (0.48) | PLA2G2ARORCALDH1A1TLR8GRM1 | |
| SCHEMBL28158605 | 0.71 | RORC (0.45) | PLA2G2ARORCALDH1A1TLR8HPGD | |
| SCHEMBL6976721 | 0.70 | CLK4 (0.43) | ALDH1A1HPGDLMNA | |
| SCHEMBL21574677 | 0.67 | PKM (0.45) | PLA2G2ARORCALDH1A1L3MBTL1POLB | |
| SCHEMBL5604221 | 0.67 | BRD4 (0.54) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909192-B1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-17 | — | — | EP | disclosed |
| US-9290476-B2 | Methylene linked quinolinyl modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-22 | — | — | US | disclosed |
| US-9290476-B2 | Methylene linked quinolinyl modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-22 | — | — | US | disclosed |
| US-9290476-B2 | Methylene linked quinolinyl modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-22 | — | — | US | disclosed |
| US-20140107094-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-17 | — | — | US | disclosed |
| US-20140107094-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-17 | — | — | US | disclosed |
| US-20140107094-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107094-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt | RORC, RORA, RORB | PLA2G2A 3685/4885RORC 1/4885HPGDS 1611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.