Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 2/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18732022 | 0.96 | LPL (0.35) | LPLLIPGEGFRPRMT5WDR77 | |
| SCHEMBL18034326 | 0.95 | LPL (0.34) | LPLLIPGEGFRPRMT5WDR77 | |
| SCHEMBL18034436 | 0.95 | LPL (0.34) | LPLLIPGEGFRPRMT5WDR77 | |
| SCHEMBL18732181 | 0.94 | LPL (0.33) | LPLLIPGEGFRPRMT5WDR77 | |
| SCHEMBL25004616 | 0.89 | LPL (0.32) | LPLLIPGPRMT5WDR77 | |
| SCHEMBL19862391 | 0.89 | PRMT5 (0.32) | LPLLIPGPRMT5WDR77 | |
| SCHEMBL18034435 | 0.88 | LIPG (0.42) | LPLLIPG | |
| SCHEMBL19862383 | 0.88 | PRMT5 (0.32) | LPLLIPGPRMT5WDR77 | |
| SCHEMBL16491819 | 0.86 | PGR (0.36) | LPLLIPGEGFRPRMT5WDR77 | |
| SCHEMBL20224572 | 0.85 | PGR (0.35) | LPLLIPGEGFRPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-11545634-B2 | Heterocyclic spiro compounds | MERCK PATENT GMBH (DE) | 2023-01-03 | — | — | US | disclosed |
| EP-3708634-A1 | HETEROCYCLIC SPIRO COMPOUNDS | Merck Patent GmbH (DE) | 2020-09-16 | — | — | EP | disclosed |
| US-10777750-B2 | Heterocyclic spiro compounds | BASF SE (DE) | 2020-09-15 | — | — | US | disclosed |
| US-20200266364-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2020-08-20 | — | — | US | disclosed |
| US-10665790-B2 | Materials for electronic devices | MERCK PATENT GMBH (DE) | 2020-05-26 | — | — | US | disclosed |
| EP-3083880-B1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2020-04-01 | — | — | EP | disclosed |
| US-9978950-B2 | Materials for electronic devices | MERCK PATENT GMBH (DE) | 2018-05-22 | — | — | US | disclosed |
| US-9978950-B2 | Materials for electronic devices | MERCK PATENT GMBH (DE) | 2018-05-22 | — | — | US | disclosed |
| US-9837617-B2 | Materials for electronic devices | MERCK PATENT GMBH (DE) | 2017-12-05 | — | — | US | disclosed |
| US-9837617-B2 | Materials for electronic devices | MERCK PATENT GMBH (DE) | 2017-12-05 | — | — | US | disclosed |
| US-20170301865-A1 | MATERIALS FOR ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| US-20170301865-A1 | MATERIALS FOR ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
| US-20160190466-A1 | MATERIALS FOR ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2016-06-30 | — | — | US | disclosed |
| US-20160190466-A1 | MATERIALS FOR ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2016-06-30 | — | — | US | disclosed |
| WO-2015090504-A2 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015022051-A1 | MATERIALS FOR ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2015-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | LPL 3935/4885LIPG 4011/4885EGFR 3784/4885 |
| US-10665790-B2 | Materials for electronic devices | SDHB, SDHA, ETFB | LPL 4271/4885LIPG 2927/4885EGFR 3789/4885 |
| US-11545634-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | LPL 3935/4885LIPG 4011/4885EGFR 3784/4885 |
| US-20200266364-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | LPL 3935/4885LIPG 4011/4885EGFR 3784/4885 |
| US-20160190466-A1 | MATERIALS FOR ELECTRONIC DEVICES | SDHB, SDHA, ETFB | LPL 4271/4885LIPG 2927/4885EGFR 3789/4885 |
| US-20170301865-A1 | MATERIALS FOR ELECTRONIC DEVICES | SDHB, SDHA, ETFB | LPL 4271/4885LIPG 2927/4885EGFR 3789/4885 |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | LPL 3935/4885LIPG 4011/4885EGFR 3784/4885 |
| US-10777750-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | LPL 3935/4885LIPG 4011/4885EGFR 3784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.