Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956211 | 0.78 | POLB (0.39) | HSD11B1ALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL30487705 | 0.78 | ALOX5AP (0.41) | ALDH1A1LMNAMAPTCNR2TSHR | |
| SCHEMBL4556987 | 0.78 | ALOX5AP (0.41) | ALDH1A1LMNAMAPTCNR2TSHR | |
| SCHEMBL27858879 | 0.76 | ABCC9 (0.54) | HSD11B1ALDH1A1HTTKDM4ELMNA | |
| SCHEMBL1465612 | 0.76 | KIF18A (0.51) | ALDH1A1HTTKDM4ELMNAMAPT | |
| SCHEMBL4616939 | 0.75 | HTR6 (0.56) | HSD11B1ALDH1A1HTTKDM4ELMNA | |
| SCHEMBL507253 | 0.75 | PTGDR2 (0.49) | HSD11B1ALDH1A1HTTKDM4ELMNA | |
| SCHEMBL709683 | 0.75 | TSHR (0.62) | ALDH1A1HTTKDM4ELMNATSHR | |
| SCHEMBL123754 | 0.73 | RAD51 (0.48) | HSD11B1ALDH1A1HTTKDM4ELMNA | |
| SCHEMBL29039874 | 0.73 | HSD11B1 (0.62) | HSD11B1ALDH1A1HTTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526945-A1 | New CRTH2 Antagonists | Almirall, S.A. (ES) | 2012-11-28 | — | — | EP | disclosed |