Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Nicomorphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 10/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.53 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nicomorphine SCHEMBL680036 | 0.99 | OPRD1 (0.69) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| Nicomorphine SCHEMBL29408441 | 0.99 | OPRD1 (0.69) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| Nicomorphine SCHEMBL29349768 | 0.99 | OPRD1 (0.69) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| Nicomorphine SCHEMBL26237 | 0.99 | OPRD1 (0.69) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| Nicomorphine SCHEMBL395672 | 0.98 | OPRD1 (0.68) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| Nicocodine SCHEMBL1023092 | 0.93 | OPRM1 (0.69) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| Nicocodine SCHEMBL159020 | 0.93 | OPRM1 (0.69) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| Nicocodine SCHEMBL29531263 | 0.93 | OPRM1 (0.69) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| SCHEMBL27496008 | 0.90 | OPRD1 (0.66) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| SCHEMBL1556900 | 0.90 | OPRD1 (0.82) | OPRD1OPRM1OPRK1ADRB1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |