Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 10/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.53 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nicomorphine SCHEMBL26237 | 1.00 | OPRD1 (0.69) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| Nicomorphine SCHEMBL29408441 | 1.00 | OPRD1 (0.69) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| Nicomorphine SCHEMBL29349768 | 1.00 | OPRD1 (0.69) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| Nicomorphine SCHEMBL1649977 | 0.99 | OPRD1 (0.68) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| Nicomorphine SCHEMBL395672 | 0.99 | OPRD1 (0.68) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| Nicocodine SCHEMBL1023092 | 0.94 | OPRM1 (0.69) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| Nicocodine SCHEMBL159020 | 0.94 | OPRM1 (0.69) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| Nicocodine SCHEMBL29531263 | 0.94 | OPRM1 (0.69) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| SCHEMBL27496008 | 0.91 | OPRD1 (0.66) | OPRD1OPRM1OPRK1ADRB1PDE4D | |
| SCHEMBL1556900 | 0.91 | OPRD1 (0.82) | OPRD1OPRM1OPRK1ADRB1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987291-B2 | Opioid-containing oral pharmaceutical compositions and methods | Upsher Smith Laboratories, Inc. (US) | 2015-03-24 | — | — | US | disclosed |
| US-8987291-B2 | Opioid-containing oral pharmaceutical compositions and methods | Upsher Smith Laboratories, Inc. (US) | 2015-03-24 | — | — | US | disclosed |
| US-20130237559-A1 | SUSTAINED RELEASE COMPOSITION COMPRISING AN AMINE AS ACTIVE AGENT AND A SALT OF A CYCLIC ORGANIC ACID | UPSHER-SMITH LABORATORIES, INC. | 2013-09-12 | — | — | US | disclosed |
| US-20130237559-A1 | SUSTAINED RELEASE COMPOSITION COMPRISING AN AMINE AS ACTIVE AGENT AND A SALT OF A CYCLIC ORGANIC ACID | UPSHER-SMITH LABORATORIES, INC. | 2013-09-12 | — | — | US | disclosed |
| US-20130123293-A1 | OPIOID-CONTAINING ORAL PHARMACEUTICAL COMPOSITIONS AND METHODS | UPSHER-SMITH LABORATORIES, INC. (US) | 2013-05-16 | — | — | US | disclosed |
| US-20130123293-A1 | OPIOID-CONTAINING ORAL PHARMACEUTICAL COMPOSITIONS AND METHODS | UPSHER-SMITH LABORATORIES, INC. (US) | 2013-05-16 | — | — | US | disclosed |
| US-8362029-B2 | Opioid-containing oral pharmaceutical compositions and methods | UPSHER-SMITH LABORATORIES, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-8362029-B2 | Opioid-containing oral pharmaceutical compositions and methods | UPSHER-SMITH LABORATORIES, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-20110275658-A1 | OPIOID-CONTAINING ORAL PHARMACEUTICAL COMPOSITIONS AND METHODS | UPSHER-SMITH LABORATORIES, INC. (US) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275658-A1 | OPIOID-CONTAINING ORAL PHARMACEUTICAL COMPOSITIONS AND METHODS | OPRK1, OPRM1, OPRL1 | OPRD1 4/4885OPRM1 2/4885OPRK1 1/4885 |
| US-20130123293-A1 | OPIOID-CONTAINING ORAL PHARMACEUTICAL COMPOSITIONS AND METHODS | OPRK1, OPRM1, OPRL1 | OPRD1 4/4885OPRM1 2/4885OPRK1 1/4885 |
| US-20130237559-A1 | SUSTAINED RELEASE COMPOSITION COMPRISING AN AMINE AS ACTIVE AGENT AND A SALT OF A CYCLIC ORGANIC ACID | OPRK1, OPRM1, OPRL1 | OPRD1 4/4885OPRM1 2/4885OPRK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.