Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATIC | P31939 | 1/20 | 0.56 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | MOGAT2 | Q3SYC2 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 1/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595509 | 0.90 | SLC22A12 (0.56) | ATICSLC22A12MEN1KMT2AKEAP1 | |
| SCHEMBL21999843 | 0.82 | ACLY (0.65) | SLC22A12LMNAMEN1KMT2AMOGAT2 | |
| SCHEMBL9209669 | 0.80 | LMNA (0.58) | LMNAMEN1KMT2AKEAP1NFE2L2 | |
| SCHEMBL5801171 | 0.80 | LMNA (0.61) | LMNAMEN1KMT2AKEAP1NFE2L2 | |
| SCHEMBL24697641 | 0.78 | MOGAT2 (0.44) | ATICSLC22A12LMNAKMT2AMOGAT2 | |
| SCHEMBL31086082 | 0.78 | MOGAT2 (0.44) | ATICSLC22A12LMNAKMT2AMOGAT2 | |
| SCHEMBL76535 | 0.78 | CYP2D6 (0.60) | LMNAMEN1KMT2AKEAP1NFE2L2 | |
| SCHEMBL7596259 | 0.77 | CCR2 (0.50) | SLC22A12ACLY | |
| SCHEMBL851450 | 0.77 | SLC22A12 (0.54) | SLC22A12MEN1KMT2AACLY | |
| SCHEMBL1818184 | 0.77 | METAP2 (0.62) | LMNAMEN1KMT2AMOGAT2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2853532-B1 | 1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III | INST FARMAKOLOGII POLSKIEJ AKADEMII NAUK (PL) | 2020-12-09 | — | — | EP | disclosed |
| EP-2853532-A1 | 1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III | Instytut Farmakologii Polskiej Akademii Nauk (PL) | 2015-04-01 | — | — | EP | disclosed |