Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.56 |
| ▸ | ATIC | P31939 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.48 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16592647 | 0.90 | ATIC (0.56) | SLC22A12ATICMEN1KMT2AKEAP1 | |
| SCHEMBL5956006 | 0.80 | KEAP1 (0.58) | MEN1KMT2AKEAP1NFE2L2 | |
| SCHEMBL7594380 | 0.79 | KEAP1 (0.62) | MEN1KMT2AKEAP1NFE2L2 | |
| SCHEMBL7587888 | 0.79 | KEAP1 (0.54) | KMT2AKEAP1NFE2L2ACLYHSD11B1 | |
| SCHEMBL7596259 | 0.78 | CCR2 (0.50) | SLC22A12ACLYPTGES2 | |
| SCHEMBL7572129 | 0.78 | GLO1 (0.60) | SLC22A12ATICACLYGLO1HSD11B1 | |
| SCHEMBL7589336 | 0.78 | SLC22A12 (0.54) | SLC22A12ACLYGLO1PTGES2 | |
| SCHEMBL851450 | 0.78 | SLC22A12 (0.54) | SLC22A12MEN1KMT2AACLY | |
| SCHEMBL7591285 | 0.77 | SLC40A1 (0.59) | MEN1KMT2AKEAP1NFE2L2ACLY | |
| SCHEMBL7590023 | 0.76 | CCR2 (0.51) | MEN1KMT2AKEAP1NFE2L2MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |