Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31372850 | 0.81 | NPSR1 (0.38) | NPC1RAB9ASMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL29601005 | 0.79 | PDK2 (0.38) | SLC6A4SLC6A3NPC1RAB9AL3MBTL1 | |
| SCHEMBL30499558 | 0.79 | SLC6A4 (0.59) | SLC6A4SLC6A3PTGS1PTGS2NPC1 | |
| SCHEMBL22290184 | 0.79 | SLC6A4 (0.59) | SLC6A4SLC6A3PTGS1PTGS2NPC1 | |
| SCHEMBL29738141 | 0.77 | NPSR1 (0.43) | NPC1RAB9ASMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL644695 | 0.77 | NPSR1 (0.43) | NPC1RAB9ASMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL18061482 | 0.77 | ALDH1A1 (0.43) | SLC6A4SLC6A3PTGS2NPC1RAB9A | |
| SCHEMBL27667113 | 0.77 | IKBKB (0.50) | SLC6A4SLC6A3PTGS2NPC1CASP3 | |
| SCHEMBL2592299 | 0.76 | AGBL2 (0.47) | NPC1CASP3RAB9ASMN1; SMN2SENP8 | |
| SCHEMBL14260604 | 0.76 | OPRK1 (0.47) | SLC6A4SLC6A3NPC1CASP3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10239863-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-03-26 | — | — | US | disclosed |
| US-10239863-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-03-26 | — | — | US | disclosed |
| US-20180179180-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | US | disclosed |
| US-20180179180-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | US | disclosed |
| US-20180179180-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | US | disclosed |
| US-20160257668-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-09-08 | — | — | US | disclosed |
| US-20160257668-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-09-08 | — | — | US | disclosed |
| US-20160257668-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-09-08 | — | — | US | disclosed |
| EP-3054944-A1 | FACTOR XIa INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015054087-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-04-16 | — | — | WO | disclosed |
| WO-2015054087-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180179180-A1 | Factor XIa Inhibitors | F11, SERPINC1, TFPI | SLC6A4 4779/4885SLC6A3 4862/4885PTGS1 789/4885 |
| US-20160257668-A1 | Factor XIa Inhibitors | F11, SERPINC1, TFPI | SLC6A4 4779/4885SLC6A3 4862/4885PTGS1 789/4885 |
| US-10239863-B2 | Factor XIa inhibitors | F11, SERPINC1, TFPI | SLC6A4 4779/4885SLC6A3 4862/4885PTGS1 789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.