SCHEMBL16640759

SCHEMBL16640759

CC(C)(C)C(=O)CCCCC(=O)C(C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
FAAH O00519 11/20 0.46
CES1 P23141 8/20 0.44
CES2 O00748 3/20 0.44
KMT2A Q03164 2/20 0.44
MEN1 O00255 1/20 0.44
CYP1A2 P05177 1/20 0.44
HSD17B10 Q99714 1/20 0.44
LMNA P02545 2/20 0.37
HSD11B1 P28845 1/20 0.37
ALDH1A1 P00352 1/20 0.36
TSHR P16473 1/20 0.35
NFKB1 P19838 1/20 0.35
PMP22 Q01453 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19163900 0.97 FAAH (0.48) FAAHCES1CES2KMT2AMEN1
SCHEMBL13661862 0.97 FAAH (0.48) FAAHCES1CES2KMT2AMEN1
SCHEMBL16722811 0.97 FAAH (0.48) FAAHCES1CES2KMT2AMEN1
SCHEMBL16640758 0.97 FAAH (0.48) FAAHCES1CES2KMT2AMEN1
SCHEMBL12247043 0.97 FAAH (0.48) FAAHCES1CES2KMT2AMEN1
SCHEMBL18751671 0.97 FAAH (0.48) FAAHCES1CES2KMT2AMEN1
SCHEMBL5021516 0.93 FAAH (0.40) FAAHCES1CES2KMT2AMEN1
SCHEMBL7256359 0.89 LMNA (0.58) KMT2AMEN1HSD17B10LMNAALDH1A1
SCHEMBL3631010 0.89 FAAH (0.62) FAAHCES1CES2KMT2AMEN1
SCHEMBL2529981 0.89 GPR84 (0.46) FAAHCES1CES2KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240209149-A1 BIO-BASED POLYAMIDE ELASTOMER AND PREPARATION METHOD THEREFOR CATHAY BIOTECH INC. (CN) 2024-06-27 US disclosed
US-20230310551-A1 INSULIN RECEPTOR PARTIAL AGONISTS MERCK SHARP & DOHME LLC (US) 2023-10-05 US disclosed
US-20210252159-A1 CONJUGATES OF CARTILAGE-HOMING PEPTIDES FRED HUTCHINSON CANCER CENTER 2021-08-19 US disclosed
US-10017556-B2 Insulin receptor partial agonists MERCK SHARP & DOHME CORP. (US) 2018-07-10 US disclosed
US-20180110863-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME CORP. (US) 2018-04-26 US disclosed
US-9950076-B2 Maytansinoid derivatives, conjugates thereof, and methods of use REGENERON PHARMACEUTICALS, INC. (US) 2018-04-24 US disclosed
US-9889205-B2 Glucose-responsive insulin conjugates MERCK SHARP & DOHME CORP. (US) 2018-02-13 US disclosed
US-9884125-B2 Glucose-responsive insulin conjugates MERCK SHARP & DOHME CORP. (US) 2018-02-06 US disclosed
US-20170355743-A1 INSULIN RECEPTOR PARTIAL AGONISTS MERCK SHARP & DOHME CORP. (US) 2017-12-14 US disclosed
US-20170254798-A1 METHOD FOR SCREENING DRUG-SACCHARIDE CONJUGATES MERCK SHARP & DOHME CORP. (US) 2017-09-07 US disclosed
US-20170248580-A1 METHOD FOR SCREENING DRUG-SACCHARIDE CONJUGATES MERCK SHARP & DOHME CORP. (US) 2017-08-31 US disclosed
US-20170209591-A1 MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE REGENERON PHARMACEUTICALS, INC. 2017-07-27 US disclosed
US-20170119907-A1 Targeted Therapeutics MEDIVATION TECHNOLOGIES, INC. (US) 2017-05-04 US disclosed
US-20170107268-A1 INSULIN RECEPTOR PARTIAL AGONISTS MERCK SHARP & DOHME CORP. (US) 2017-04-20 US disclosed
US-20160375147-A1 MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE REGENERON PHARMACEUTICALS, INC. 2016-12-29 US disclosed
US-20160303244-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME CORP. (US) 2016-10-20 US disclosed
US-20160251407-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME CORP. (US) 2016-09-01 US disclosed
US-9427475-B2 Glucose-responsive insulin conjugates MERCK SHARP & DOHME CORP. (US) 2016-08-30 US disclosed
US-20150105317-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME LLC 2015-04-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160375147-A1 MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE SLC10A1, HNMT, OGFR FAAH 2211/4885CES1 543/4885CES2 363/4885
US-20180110863-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES GPR119, INSR, IRS1 FAAH 4547/4885CES1 871/4885CES2 974/4885
US-20150105317-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES GPR119, INSR, IRS1 FAAH 4668/4885CES1 854/4885CES2 876/4885
US-20170209591-A1 MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE HNMT, SLC10A1, SLC10A2 FAAH 2231/4885CES1 609/4885CES2 406/4885
US-20160251407-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES GPR119, INSR, IRS1 FAAH 4675/4885CES1 1190/4885CES2 1207/4885
US-20210252159-A1 CONJUGATES OF CARTILAGE-HOMING PEPTIDES CD44, MATR3, CCL2 FAAH 3675/4885CES1 2239/4885CES2 3077/4885
US-20170355743-A1 INSULIN RECEPTOR PARTIAL AGONISTS INSR, GPR119, IRS1 FAAH 2626/4885CES1 1697/4885CES2 2734/4885
US-20170119907-A1 Targeted Therapeutics ANXA3, ANXA5, ANXA6 FAAH 3179/4885CES1 3839/4885CES2 2041/4885
US-10017556-B2 Insulin receptor partial agonists INSR, GPR119, IRS1 FAAH 2626/4885CES1 1697/4885CES2 2734/4885
US-20170107268-A1 INSULIN RECEPTOR PARTIAL AGONISTS INSR, GPR119, IRS1 FAAH 2626/4885CES1 1697/4885CES2 2734/4885
US-20230310551-A1 INSULIN RECEPTOR PARTIAL AGONISTS INSR, GPR119, IRS1 FAAH 2626/4885CES1 1697/4885CES2 2734/4885
US-20160303244-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES GPR119, INSR, IRS1 FAAH 4668/4885CES1 854/4885CES2 876/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.