Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.38 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | CHUK | O15111 | 2/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.36 |
| ▸ | CCNK | O75909 | 2/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16655428 | 0.83 | AURKB (0.46) | AURKBAURKAPIK3C3JAK2JAK3 | |
| SCHEMBL16655277 | 0.82 | AURKB (0.44) | AURKBAURKAPIK3C3JAK2JAK3 | |
| SCHEMBL1647776 | 0.80 | MAPK14 (0.59) | AURKBAURKAPIK3C3INCENPBRAF | |
| SCHEMBL16655160 | 0.78 | NUDT1 (0.46) | AURKBAURKAJAK3JAK1BRAF | |
| SCHEMBL1648278 | 0.78 | AURKB (0.48) | AURKBAURKAPIK3C3INCENPTPX2 | |
| SCHEMBL16655062 | 0.77 | AURKB (0.57) | AURKBAURKAPIK3C3JAK2JAK3 | |
| SCHEMBL1646703 | 0.77 | NUDT1 (0.53) | AURKBAURKAPIK3C3JAK2JAK3 | |
| SCHEMBL1648143 | 0.75 | BRAF (0.46) | AURKBAURKAJAK2JAK3BRAF | |
| SCHEMBL14313780 | 0.69 | ALDH1A1 (0.40) | CD274RET | |
| SCHEMBL16100426 | 0.69 | ALDH1A1 (0.34) | CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9440977-B2 | Compositions, uses and methods for their preparation | SHENGYUAN PHARMACEUTICAL GUANGZHOU LTD CO. (CN) | 2016-09-13 | — | — | US | disclosed |
| US-9440977-B2 | Compositions, uses and methods for their preparation | SHENGYUAN PHARMACEUTICAL GUANGZHOU LTD CO. (CN) | 2016-09-13 | — | — | US | disclosed |
| EP-3057972-A1 | NOVEL COMPOSITIONS, USES AND METHODS FOR THEIR PREPARATION | Jin, V (US) | 2016-08-24 | — | — | EP | disclosed |
| US-20160229855-A1 | NOVEL COMPOSITIONS, USES AND METHODS FOR THEIR PREPARATION | Jin, Bohan (US) | 2016-08-11 | — | — | US | disclosed |
| US-20160229855-A1 | NOVEL COMPOSITIONS, USES AND METHODS FOR THEIR PREPARATION | Jin, Bohan (US) | 2016-08-11 | — | — | US | disclosed |
| WO-2015057695-A1 | NOVEL COMPOSITIONS, USES AND METHODS FOR THEIR PREPARATION | JIN BOHAN (US) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015057695-A1 | NOVEL COMPOSITIONS, USES AND METHODS FOR THEIR PREPARATION | JIN BOHAN (US) | 2015-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229855-A1 | NOVEL COMPOSITIONS, USES AND METHODS FOR THEIR PREPARATION | LIPA, PNLIP, LIPC | AURKB 4636/4885AURKA 4788/4885PIK3C3 2373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.