Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.44 |
| ▸ | AURKA | O14965 | 4/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.40 |
| ▸ | CIT | O14578 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | CHUK | O15111 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16655428 | 0.83 | AURKB (0.46) | AURKBAURKANUDT1PIK3C3INCENP | |
| SCHEMBL16655108 | 0.82 | AURKB (0.42) | AURKBAURKANUDT1PIK3C3INCENP | |
| SCHEMBL16655160 | 0.80 | NUDT1 (0.46) | AURKBAURKANUDT1JAK3BRAF | |
| SCHEMBL1647776 | 0.80 | MAPK14 (0.59) | AURKBAURKAPIK3C3INCENPIGF1R | |
| SCHEMBL1648278 | 0.79 | AURKB (0.48) | AURKBAURKAPIK3C3INCENPTPX2 | |
| SCHEMBL16655062 | 0.79 | AURKB (0.57) | AURKBAURKANUDT1PIK3C3INCENP | |
| SCHEMBL1646703 | 0.77 | NUDT1 (0.53) | AURKBAURKANUDT1PIK3C3JAK2 | |
| SCHEMBL1648143 | 0.75 | BRAF (0.46) | AURKBAURKANUDT1JAK2JAK3 | |
| SCHEMBL25179442 | 0.69 | CYP4F2 (0.37) | FGFR1KDRBRAFCD274 | |
| SCHEMBL31413853 | 0.69 | ALDH1A1 (0.36) | RETFGFR1KDRCD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9440977-B2 | Compositions, uses and methods for their preparation | SHENGYUAN PHARMACEUTICAL GUANGZHOU LTD CO. (CN) | 2016-09-13 | — | — | US | disclosed |
| US-9440977-B2 | Compositions, uses and methods for their preparation | SHENGYUAN PHARMACEUTICAL GUANGZHOU LTD CO. (CN) | 2016-09-13 | — | — | US | disclosed |
| EP-3057972-A1 | NOVEL COMPOSITIONS, USES AND METHODS FOR THEIR PREPARATION | Jin, V (US) | 2016-08-24 | — | — | EP | disclosed |
| US-20160229855-A1 | NOVEL COMPOSITIONS, USES AND METHODS FOR THEIR PREPARATION | Jin, Bohan (US) | 2016-08-11 | — | — | US | disclosed |
| US-20160229855-A1 | NOVEL COMPOSITIONS, USES AND METHODS FOR THEIR PREPARATION | Jin, Bohan (US) | 2016-08-11 | — | — | US | disclosed |
| WO-2015057695-A1 | NOVEL COMPOSITIONS, USES AND METHODS FOR THEIR PREPARATION | JIN BOHAN (US) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015057695-A1 | NOVEL COMPOSITIONS, USES AND METHODS FOR THEIR PREPARATION | JIN BOHAN (US) | 2015-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229855-A1 | NOVEL COMPOSITIONS, USES AND METHODS FOR THEIR PREPARATION | LIPA, PNLIP, LIPC | AURKB 4636/4885AURKA 4788/4885NUDT1 207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.