Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.50 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10117774 | 0.80 | ALDH1A1 (0.42) | RAB9ADYRK1AKMT2AGAACYP1A2 | |
| SCHEMBL4519009 | 0.80 | ADORA3 (0.53) | RAB9AKMT2ALMNAMAPTMEN1 | |
| SCHEMBL2380377 | 0.80 | ADORA3 (0.54) | RAB9ADYRK1AKMT2AGAAMAPT | |
| SCHEMBL8012523 | 0.80 | XDH (0.44) | KMT2AGAALMNAMAPTMEN1 | |
| SCHEMBL1201878 | 0.80 | ADORA3 (0.55) | RAB9AKMT2AGAALMNAMAPT | |
| SCHEMBL10602903 | 0.78 | MAPT (0.46) | RAB9ADYRK1AKMT2ALMNAMAPT | |
| SCHEMBL8012036 | 0.77 | LMNA (0.41) | KMT2AGAALMNAMAPTMEN1 | |
| SCHEMBL6238340 | 0.77 | ADORA3 (0.56) | DYRK1AKMT2AMAPTMEN1KDM4E | |
| SCHEMBL6152117 | 0.77 | EGLN2 (0.45) | RAB9ADYRK1AKMT2AGAALMNA | |
| SCHEMBL8017036 | 0.76 | MAPT (0.51) | RAB9AKMT2AGAALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150183770-A1 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2015-07-02 | — | — | US | disclosed |
| US-8921406-B2 | 5-ring heteroaromatic compounds and their use as binding partners for 5-HT5 receptors | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-12-30 | — | — | US | disclosed |
| EP-1917251-B1 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBOTT GMBH & CO KG (DE) | 2013-04-03 | — | — | EP | disclosed |
| US-20110207788-A1 | 5-Ring Heteroaromatic compounds and their use as binding partners for 5-ht5 receptors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2011-08-25 | — | — | US | disclosed |
| EP-2308852-A1 | 5-ring heteroaromatic compounds and their use as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-04-13 | — | — | EP | disclosed |
| EP-1917251-A2 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | Abbott GmbH & Co. KG (DE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007022947-A2 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2007-03-01 | — | — | WO | disclosed |
| US-6043254-A | ANTIPROLIFERATIVE AGENT; ENZYME INHIBITOR | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-28 | — | — | US | disclosed |
| EP-0131973-B1 | NEW AMIDINE DERIVATIVES OF 2-SUBSTITUTED 4-PHENILIMIDAZOLE | ISTITUTO DE ANGELI S.p.A. (IT) | 1989-08-02 | — | — | EP | disclosed |
| US-4649150-A | ANTISECRETORY AGENTS | ISTITUTO DE ANGELI, S.P.A. (IT) | 1987-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183770-A1 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | HTR5A, HTR3A, HTR6 | RAB9A 3409/4885DYRK1A 2561/4885CSNK2A2 2456/4885 |
| US-20110207788-A1 | 5-Ring Heteroaromatic compounds and their use as binding partners for 5-ht5 receptors | HTR5A, HTR3A, HTR6 | RAB9A 3409/4885DYRK1A 2561/4885CSNK2A2 2456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.