Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8573937 | 0.73 | TDP1 (0.41) | MEN1KMT2AMAPTALOX15HSD17B10 | |
| SCHEMBL1062170 | 0.73 | TDP1 (0.44) | MEN1KMT2AMAPTALOX15HSD17B10 | |
| SCHEMBL239691 | 0.69 | HTT (0.48) | MEN1KMT2AMAPTALOX15HSD17B10 | |
| SCHEMBL9635435 | 0.69 | HSD17B10 (0.49) | MEN1KMT2AALOX15HSD17B10ALDH1A1 | |
| SCHEMBL176287 | 0.68 | ADRA2C (0.47) | MEN1KMT2AMAPTADRA2BADRA2C | |
| SCHEMBL15022038 | 0.68 | TDP1 (0.52) | MEN1KMT2AALOX15HSD17B10TDP1 | |
| SCHEMBL7965647 | 0.66 | ADRA2B (0.40) | MEN1PKMKMT2AMAPTALOX15 | |
| SCHEMBL15540408 | 0.66 | HTT (0.49) | MEN1KMT2AMAPTTDP1CYP11B1 | |
| SCHEMBL7597344 | 0.65 | HSD17B10 (0.54) | MAPTALOX15HSD17B10NPSR1ALDH1A1 | |
| SCHEMBL11844044 | 0.65 | ALOX15 (0.55) | KMT2AMAPTALOX15HSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150183770-A1 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2015-07-02 | — | — | US | disclosed |
| US-8921406-B2 | 5-ring heteroaromatic compounds and their use as binding partners for 5-HT5 receptors | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-12-30 | — | — | US | disclosed |
| EP-1917251-B1 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBOTT GMBH & CO KG (DE) | 2013-04-03 | — | — | EP | disclosed |
| US-20110207788-A1 | 5-Ring Heteroaromatic compounds and their use as binding partners for 5-ht5 receptors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2011-08-25 | — | — | US | disclosed |
| EP-2308852-A1 | 5-ring heteroaromatic compounds and their use as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-04-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183770-A1 | 5-RING HETEROAROMATIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | HTR5A, HTR3A, HTR6 | MEN1 2890/4885PKM 3299/4885KMT2A 4010/4885 |
| US-20110207788-A1 | 5-Ring Heteroaromatic compounds and their use as binding partners for 5-ht5 receptors | HTR5A, HTR3A, HTR6 | MEN1 2890/4885PKM 3299/4885KMT2A 4010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.