Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.56 |
| ▸ | DAO | P14920 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.39 |
| ▸ | PDE8A | O60658 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.39 |
| ▸ | PDE8B | O95263 | 1/20 | 0.39 |
| ▸ | PDE6A | P16499 | 1/20 | 0.39 |
| ▸ | PDE6G | P18545 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE6B | P35913 | 1/20 | 0.39 |
| ▸ | PDE6C | P51160 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2898417 | 0.98 | ATAD2 (0.54) | ATAD2DAOPARP1PDE2APDE6D | |
| SCHEMBL27791126 | 0.88 | ATAD2 (0.46) | ATAD2DAOPARP1PDE2APDE6D | |
| Isoxazole SCHEMBL29144694 | 0.86 | ATAD2 (0.44) | ATAD2DAOPARP1PDE2APDE6D | |
| Aminothiazole SCHEMBL29250377 | 0.84 | ATAD2 (0.43) | ATAD2DAOPARP1FGFR1KDM4E | |
| Trifluoromethanesulfonic Acid SCHEMBL5258752 | 0.84 | DAO (0.43) | ATAD2DAOPARP1FGFR1KDM4E | |
| Quinoline SCHEMBL18171691 | 0.79 | ALDH1A1 (0.55) | ATAD2DAOPARP1FGFR1ALDH1A1 | |
| SCHEMBL18035168 | 0.74 | ATAD2 (0.35) | ATAD2DAOPDE3BPDE3A | |
| SCHEMBL29937409 | 0.74 | ATAD2 (0.35) | ATAD2DAOPDE3BPDE3A | |
| SCHEMBL31042178 | 0.73 | DAO (0.53) | ATAD2DAOPARP1PDE2APDE6D | |
| SCHEMBL586351 | 0.73 | DAO (0.53) | ATAD2DAOPARP1PDE2APDE6D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4363043-B1 | COMPOSITIONS FOR USE IN METHODS FOR INCREASING CANCER CELL SENSITIVITY TO ALTERNATING ELECTRIC FIELDS | NOVOCURE GMBH (CH) | 2026-04-22 | — | — | EP | claimed |
| EP-4653437-A2 | NOVEL HETEROCYCLIC COMPOUNDS | Innovo Therapeutics Inc. (KR) | 2025-11-26 | — | — | EP | claimed |
| US-20250325572-A1 | TREATMENTS FOR PAIN | SEVENLESS THERAPEUTICS LTD (GB) | 2025-10-23 | — | — | US | claimed |
| EP-4021901-B1 | SUBSTITUTED PYRIDOPYRIMIDINONYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2025-09-24 | — | — | EP | claimed |
| EP-4598538-A1 | NEW TREATMENTS FOR PAIN | Sevenless Therapeutics Limited (GB) | 2025-08-13 | — | — | EP | claimed |
| US-12338246-B2 | Pyrazine derivative and application thereof in inhibiting SHP2 | SUZHOU GENHOUSE PHARMACEUTICAL CO., LTD. (CN) | 2025-06-24 | — | — | US | claimed |
| EP-4072546-B1 | INHIBITORS OF KDM5A FOR USE IN TREATMENT OF IDIOPATHIC INFLAMMATORY MYOPATHIES | UNIV ANTWERPEN (BE) | 2025-02-19 | — | — | EP | claimed |
| CN-118084902-B | 2-Aminothiazole pyrimidopyridone compound or pharmaceutically acceptable salt or stereoisomer, preparation method and application | 赣南师范大学 | 2024-10-29 | — | — | CN | claimed |
| CN-118580239-A | Pyrimidopyridone derivative PDE5 inhibitor and application thereof | 常州亚邦制药有限公司 | 2024-09-03 | — | — | CN | claimed |
| WO-2024175999-A2 | BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF | DUNAD THERAPEUTICS LTD. (GB) | 2024-08-29 | — | — | WO | claimed |
| CN-1252069-C | 2-aryl-naphthyridin-4-ones as antitumor agents | UNIV NORTH CAROLINA CHAPEL HILL (US) | 2006-04-19 | — | — | CN | claimed |
| US-20050176957-A1 | Process for the preparation of pyridopyrimidones | SCIOS INC. | 2005-08-11 | — | — | US | claimed |
| WO-2005065416-A2 | PROCESS FOR THE PREPARATION OF PYRIDOPYRIMIDONES | SCIOS INC. (US) | 2005-07-21 | — | — | WO | claimed |
| US-20050107350-A1 | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith | PHARMACIA CORPORATION (US) | 2005-05-19 | — | — | US | claimed |
| CN-1309561-A | Therapeutic agent for erectile dysfunction | MOCHIDA PHARM CO LTD (JP) | 2001-08-22 | — | — | CN | claimed |
| CN-1259947-A | 2-aryl-naphthyridin-4-ones as antitumor agents | UNIV NORTH CAROLINA CHAPEL HILL (US) | 2000-07-12 | — | — | CN | claimed |
| US-6071930-A | FOR INHIBITION OF MITOSIS OR TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-06-06 | — | — | US | claimed |
| EP-0992240-A1 | THERAPEUTIC AGENT FOR ERECTION FAILURE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-12 | — | — | EP | claimed |
| EP-0971921-A1 | 2-ARYL-NAPHTHYRIDIN-4-ONES AS ANTITUMOR AGENTS | The University of North Carolina at Chapel Hill (US) | 2000-01-19 | — | — | EP | claimed |
| WO-1998039332-A1 | 2-ARYL-NAPHTHYRIDIN-4-ONES AS ANTITUMOR AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-09-11 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12338246-B2 | Pyrazine derivative and application thereof in inhibiting SHP2 | PTPN5, PTPN1, PTPN7 | ATAD2 3825/4885DAO 2469/4885PARP1 4845/4885 |
| US-20250325572-A1 | TREATMENTS FOR PAIN | OPRL1, ACHE, OPRK1 | ATAD2 4098/4885DAO 1724/4885PARP1 4453/4885 |
| US-20050176957-A1 | Process for the preparation of pyridopyrimidones | PDXK, PNPO, AGPS | ATAD2 721/4885DAO 465/4885PARP1 611/4885 |
| US-20050107350-A1 | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith | PTGS2, PTGES2, PTGS1 | ATAD2 2265/4885DAO 1652/4885PARP1 3401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.