Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22548445 | 1.00 | GAA (0.50) | GAAALDH1A1FFAR2KMT2AMEN1 | |
| SCHEMBL16718945 | 1.00 | GAA (0.50) | GAAALDH1A1FFAR2KMT2AMEN1 | |
| SCHEMBL19318729 | 0.98 | GAA (0.52) | GAAALDH1A1FFAR2KMT2AMEN1 | |
| SCHEMBL19318751 | 0.93 | GAA (0.54) | GAAALDH1A1FFAR2KMT2AMEN1 | |
| SCHEMBL7273957 | 0.85 | ALDH1A1 (0.46) | GAAALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11148487 | 0.81 | HSD11B1 (0.46) | ALDH1A1PTGS2 | |
| SCHEMBL7266457 | 0.81 | LMNA (0.41) | GAARAPGEF4PKMPTGS2CYP3A4 | |
| SCHEMBL10673707 | 0.80 | HTR6 (0.48) | GAAALDH1A1FFAR2KMT2AMEN1 | |
| SCHEMBL8031497 | 0.79 | HSD11B1 (0.43) | ALDH1A1PTGS2 | |
| SCHEMBL17849720 | 0.75 | GAA (0.65) | GAAALDH1A1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11850216-B2 | 18F labeling of proteins using sortases | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-12-26 | — | — | US | disclosed |
| US-20200384137-A1 | 18F LABELING OF PROTEINS USING SORTASES | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2020-12-10 | — | — | US | disclosed |
| US-10556024-B2 | 18F labeling of proteins using sortases | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2020-02-11 | — | — | US | disclosed |
| US-20160287734-A1 | 18F LABELING OF PROTEINS USING SORTASES | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2016-10-06 | — | — | US | disclosed |
| WO-2015073746-A9 | 18F LABELING OF PROTEINS USING SORTASES | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2015-07-23 | — | — | WO | disclosed |
| WO-2015073746-A2 | 18F LABELING OF PROTEINS USING SORTASES | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2015-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11850216-B2 | 18F labeling of proteins using sortases | SORT1, ANPEP, SPG11 | GAA 190/4885ALDH1A1 2873/4885FFAR2 2038/4885 |
| US-20160287734-A1 | 18F LABELING OF PROTEINS USING SORTASES | SORT1, ANPEP, SPG11 | GAA 202/4885ALDH1A1 2875/4885FFAR2 1974/4885 |
| US-20200384137-A1 | 18F LABELING OF PROTEINS USING SORTASES | SORT1, ANPEP, SPG11 | GAA 190/4885ALDH1A1 2873/4885FFAR2 2038/4885 |
| US-10556024-B2 | 18F labeling of proteins using sortases | SORT1, ANPEP, SPG11 | GAA 202/4885ALDH1A1 2875/4885FFAR2 1974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.