Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.58 |
| ▸ | SPR | P35270 | 1/20 | 0.57 |
| ▸ | KDM5A | P29375 | 1/20 | 0.55 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.54 |
| ▸ | KDM2A | Q9Y2K7 | 7/20 | 0.52 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | KDM6B | O15054 | 5/20 | 0.50 |
| ▸ | KDM5C | P41229 | 5/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.50 |
| ▸ | KDM4A | O75164 | 4/20 | 0.50 |
| ▸ | KDM3A | Q9Y4C1 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166763 | 0.86 | RBP4 (0.56) | NAMPTSPRKDM5ASCD5HSD11B1 | |
| SCHEMBL16565554 | 0.82 | ACHE (0.56) | NAMPTSPRL3MBTL3KDM2ASCD5 | |
| SCHEMBL2806341 | 0.81 | HSD11B1 (0.60) | NAMPTSPRKDM5ASCD5HSD11B1 | |
| SCHEMBL29640084 | 0.77 | HSD11B1 (0.59) | NAMPTSPRKDM5ASCD5HSD11B1 | |
| SCHEMBL26315228 | 0.77 | L3MBTL3 (0.64) | NAMPTL3MBTL3HSD11B1KDM4EL3MBTL1 | |
| SCHEMBL4074303 | 0.75 | HSD11B1 (0.53) | NAMPTSPRKDM5ASCD5HSD11B1 | |
| SCHEMBL17888462 | 0.75 | PROKR1 (0.58) | NAMPTKDM5AKDM4EMAP3K12 | |
| SCHEMBL17195702 | 0.74 | NAMPT (1.00) | NAMPT | |
| SCHEMBL19961308 | 0.74 | ALDH1A1 (0.67) | SPRKDM5AKDM2AHSD11B1KDM6B | |
| SCHEMBL6347014 | 0.74 | HSD11B1 (0.53) | NAMPTSPRKDM5AHSD11B1MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611441-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |
| US-20120053200-A1 | BACE 2 INHIBITORS | HOFFMANN-LA ROCHE INC. | 2012-03-01 | — | — | US | disclosed |
| US-20120053200-A1 | BACE 2 INHIBITORS | HOFFMANN-LA ROCHE INC. | 2012-03-01 | — | — | US | disclosed |
| US-20120053200-A1 | BACE 2 INHIBITORS | HOFFMANN-LA ROCHE INC. | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053200-A1 | BACE 2 INHIBITORS | BACE2, BACE1, PSEN2 | NAMPT 1414/4885SPR 1786/4885KDM5A 3063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.