Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735578 | 0.88 | POLB (0.56) | POLBHSP90AA1RIPK1ALDH1A1LMNA | |
| SCHEMBL16735619 | 0.84 | POLB (0.52) | POLBHSP90AA1RAB9AKDM4EGRM4 | |
| SCHEMBL16735667 | 0.82 | POLB (0.51) | POLBALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL8120522 | 0.82 | NPC1 (0.62) | POLBHSP90AA1HSP90AB1ALDH1A1LMNA | |
| SCHEMBL16735593 | 0.81 | RXFP1 (0.56) | POLB | |
| SCHEMBL16735647 | 0.81 | POLB (0.49) | POLBHSP90AA1ALDH1A1LMNARAB9A | |
| SCHEMBL16735636 | 0.81 | HSP90AA1 (0.62) | POLBHSP90AA1HSP90AB1 | |
| SCHEMBL16735605 | 0.80 | POLB (0.51) | POLBALDH1A1 | |
| SCHEMBL31428757 | 0.79 | RIPK1 (0.59) | POLBRIPK1MKNK1MKNK2SMN1; SMN2 | |
| SCHEMBL6984876 | 0.79 | MKNK1 (0.62) | RIPK1MKNK1MKNK2CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |