Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735578 | 0.87 | POLB (0.56) | POLBHSP90AA1RXFP1KDM4ETP53 | |
| SCHEMBL16735658 | 0.84 | POLB (0.53) | POLBGRM4HSP90AA1KDM4ERAB9A | |
| SCHEMBL16735667 | 0.81 | POLB (0.51) | POLBRXFP1KDM4ETP53RAB9A | |
| SCHEMBL16735647 | 0.80 | POLB (0.49) | POLBHSP90AA1RXFP1KDM4ERAB9A | |
| SCHEMBL16735593 | 0.80 | RXFP1 (0.56) | POLBRXFP1HPGD | |
| SCHEMBL31428718 | 0.80 | HPGD (0.55) | POLBHPGD | |
| SCHEMBL16735636 | 0.80 | HSP90AA1 (0.62) | POLBHSP90AA1 | |
| SCHEMBL16735605 | 0.79 | POLB (0.51) | POLBRXFP1L3MBTL1 | |
| SCHEMBL16735639 | 0.77 | RXFP1 (0.46) | POLBHSP90AA1RXFP1MCL1HRH4 | |
| SCHEMBL16735649 | 0.76 | POLB (0.46) | POLBGRM4HSP90AA1RXFP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |