Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | F11 | P03951 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735593 | 0.88 | RXFP1 (0.56) | POLBRXFP1HTR2AHTR2CSPR | |
| SCHEMBL16735667 | 0.88 | POLB (0.51) | POLBRXFP1CTSBALDH1A1KDM4E | |
| SCHEMBL16735578 | 0.84 | POLB (0.56) | POLBRXFP1LMNAALDH1A1KDM4E | |
| SCHEMBL16735605 | 0.83 | POLB (0.51) | POLBRXFP1ALDH1A1SPR | |
| SCHEMBL16735663 | 0.81 | RXFP1 (0.45) | POLBRXFP1LMNA | |
| SCHEMBL16735658 | 0.81 | POLB (0.53) | POLBLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL16735619 | 0.80 | POLB (0.52) | POLBRXFP1KDM4ERAB9AHSP90AA1 | |
| SCHEMBL16735670 | 0.80 | MAPT (0.55) | POLBRXFP1LMNAALDH1A1KDM4E | |
| SCHEMBL2143765 | 0.79 | ALDH1A1 (0.51) | CTSBALDH1A1HTR2AHTR2C | |
| SCHEMBL16735634 | 0.79 | KDM4C (0.54) | POLBRXFP1SPRMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |