Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735658 | 0.88 | POLB (0.53) | POLBMAPTKDM4EHSP90AA1ALDH1A1 | |
| SCHEMBL16735619 | 0.87 | POLB (0.52) | POLBKDM4EHSP90AA1HPGDCYP2C9 | |
| SCHEMBL16735667 | 0.86 | POLB (0.51) | POLBMAPTKDM4EHPGDRXFP1 | |
| SCHEMBL16735649 | 0.85 | POLB (0.46) | POLBMAPTKDM4EGAAHSP90AA1 | |
| SCHEMBL16735670 | 0.84 | MAPT (0.55) | POLBMAPTKDM4EGAAHPGD | |
| SCHEMBL16735647 | 0.84 | POLB (0.49) | POLBMAPTKDM4EHSP90AA1CYP2C9 | |
| SCHEMBL16735593 | 0.84 | RXFP1 (0.56) | POLBHPGDRXFP1 | |
| SCHEMBL16735636 | 0.84 | HSP90AA1 (0.62) | POLBHSP90AA1 | |
| SCHEMBL16735639 | 0.83 | RXFP1 (0.46) | POLBHSP90AA1RXFP1LMNADPP4 | |
| SCHEMBL16735605 | 0.83 | POLB (0.51) | POLBRXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |