SCHEMBL16794889

SCHEMBL16794889

CCOC(=O)n1c2ccccc2c2[nH]c(=O)c(C)c(-c3cccc(S(N)(=O)=O)c3)c21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 1/20 0.40
BRD4 O60885 1/20 0.40
AURKA O14965 1/20 0.38
AURKB Q96GD4 1/20 0.38
CA1 P00915 7/20 0.37
CA2 P00918 7/20 0.37
CA12 O43570 4/20 0.37
CA6 P23280 2/20 0.37
CA7 P43166 2/20 0.37
CA13 Q8N1Q1 1/20 0.37
CA9 Q16790 4/20 0.37
DAO P14920 2/20 0.36
AOC3 Q16853 2/20 0.36
LOXL2 Q9Y4K0 2/20 0.36
MEN1 O00255 1/20 0.36
ALDH1A1 P00352 1/20 0.36
KMT2A Q03164 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
TTK P33981 2/20 0.36
MAPK8 P45983 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16814655 0.88 ALDH1A1 (0.44) NTRK1MEN1ALDH1A1KMT2AL3MBTL1
SCHEMBL16794891 0.85 NTRK1 (0.41) NTRK1MEN1ALDH1A1KMT2AL3MBTL1
SCHEMBL16794875 0.80 NTRK1 (0.37) NTRK1MEN1ALDH1A1KMT2AL3MBTL1
SCHEMBL16794866 0.79 NOD2 (0.40) NTRK1CA1CA2MEN1KMT2A
SCHEMBL14397606 0.74 ALDH1A1 (0.51) NTRK1MEN1ALDH1A1KMT2AL3MBTL1
SCHEMBL16794967 0.73 NTRK1 (0.48) NTRK1MEN1ALDH1A1KMT2AL3MBTL1
SCHEMBL16795001 0.72 TTK (0.48) BRD4CA1CA2CA12CA9
SCHEMBL16794922 0.70 MMP2 (0.36) NTRK1MEN1ALDH1A1KMT2A
SCHEMBL16794840 0.68 NTRK1 (0.43) NTRK1MEN1ALDH1A1KMT2AL3MBTL1
SCHEMBL14397205 0.67 ALDH1A1 (0.42) NTRK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015088564-A1 P2X4 RECEPTOR MODULATING COMPOUNDS SUNOVION PHARMACEUTICALS INC. (US) 2015-06-18 WO disclosed