Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28025294 | 0.88 | POLB (0.48) | POLBRAB9AL3MBTL1ADORA3TP53 | |
| SCHEMBL5725231 | 0.86 | RAB9A (0.66) | POLBRAB9AL3MBTL1ADORA3TP53 | |
| SCHEMBL17355102 | 0.84 | ADORA3 (0.51) | POLBRAB9AL3MBTL1ADORA3TP53 | |
| SCHEMBL28466328 | 0.83 | ALPL (0.58) | POLBRAB9AL3MBTL1ADORA3TP53 | |
| SCHEMBL15192462 | 0.82 | POLB (0.43) | POLBRAB9AL3MBTL1ADORA3TP53 | |
| Hydrochloric Acid SCHEMBL9124767 | 0.81 | ALPL (0.56) | POLBRAB9AL3MBTL1ADORA3TP53 | |
| SCHEMBL238785 | 0.81 | MKNK2 (0.47) | POLBRAB9AL3MBTL1ADORA3LMNA | |
| SCHEMBL1392639 | 0.80 | ADORA3 (0.56) | POLBRAB9AL3MBTL1ADORA3TP53 | |
| SCHEMBL28142163 | 0.80 | L3MBTL1 (0.44) | POLBRAB9AL3MBTL1ADORA3TP53 | |
| SCHEMBL15192023 | 0.80 | ALDH1A1 (0.53) | POLBRAB9AL3MBTL1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 655 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111808259-B | 3D printing silicone rubber and preparation method and application thereof | 四川大学 | 2021-10-12 | — | — | CN | claimed |
| CN-111808259-A | 3D printing silicone rubber and preparation method and application thereof | 四川大学 | 2020-10-23 | — | — | CN | claimed |
| CN-105209440-B | Halopyrazoles as Thrombin Inhibitors | 维颂公司 | 2019-07-23 | — | — | CN | claimed |
| US-9486892-B2 | Polishing composition | FUJIMI INCORPORATED (JP) | 2016-11-08 | — | — | US | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1958939-A2 | Pyrazole-amine compounds for the treatment of neurodegenerative disorders | Pfizer Products Inc. (US) | 2008-08-20 | — | — | EP | claimed |
| EP-1735285-B1 | PYRAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PROD INC (US) | 2008-07-23 | — | — | EP | claimed |
| EP-1879869-A1 | PROCESS FOR THE PREPARATION OF 5-ALKYLTHIOALKYLAMINO-1-PHENYL-PYRAZOLES | Merial Limited (US) | 2008-01-23 | — | — | EP | claimed |
| US-20070270474-A1 | drugs have beta-amyloid peptide production inhibitory activity, such as 2-(2-benzo[b]thiophen-4-yl-acetylamino)-N-(5-phenyl-2H-pyrazol-3-yl)-propionamide, useful for treatment of Alzheimer's disease and Down's Syndrome | PFIZER INC. | 2007-11-22 | — | — | US | claimed |
| US-20070265327-A1 | PYRAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER INC. | 2007-11-15 | — | — | US | claimed |
| WO-2006119862-A1 | PROCESS FOR THE PREPARATION OF 5-ALKYLTHIOALKYLAMINO-1-PHENYL-PYRAZOLES | MERIAL LTD. (US) | 2006-11-16 | — | — | WO | claimed |
| US-7009052-B2 | Sulfonamide derivatives | WARNER LAMBERT COMPANY LLC (US) | 2006-03-07 | — | — | US | claimed |
| WO-2005095348-A2 | PYRAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | claimed |
| US-20050222239-A1 | Pyrazole-amine compounds for the treatment of neurodegenerative disorders | PFIZER INC | 2005-10-06 | — | — | US | claimed |
| EP-1551809-A1 | PYRAZOLE COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Inc. (US) | 2005-07-13 | — | — | EP | claimed |
| US-20050004367-A1 | Sulfonamide derivatives | DU DANIEL Y (US) | 2005-01-06 | — | — | US | claimed |
| US-20040142997-A1 | Pyrazole compounds for treatment of neurodegenerative disorders | PFIZER INC. | 2004-07-22 | — | — | US | claimed |
| WO-2004033434-A1 | PYRAZOLE COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2004-04-22 | — | — | WO | claimed |
| EP-0335156-A1 | 5-Amino-1-phenylpyrazoles | BAYER AG (DE) | 1989-10-04 | — | — | EP | claimed |
| EP-0243636-A1 | 1-Aryl-4-trifluoromethyl-5-amino pyrazoles as pesticides | BAYER AG (DE) | 1987-11-04 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222239-A1 | Pyrazole-amine compounds for the treatment of neurodegenerative disorders | APP, PRNP, BACE1 | POLB 2701/4885RAB9A 1019/4885L3MBTL1 1231/4885 |
| US-20050004367-A1 | Sulfonamide derivatives | AR, SULT2A1, SHBG | POLB 4297/4885RAB9A 4383/4885L3MBTL1 4731/4885 |
| US-20040142997-A1 | Pyrazole compounds for treatment of neurodegenerative disorders | APP, PARK7, BACE1 | POLB 3819/4885RAB9A 429/4885L3MBTL1 2169/4885 |
| US-20070265327-A1 | PYRAZOLE-AMINE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | APP, PRNP, BACE1 | POLB 2701/4885RAB9A 1019/4885L3MBTL1 1231/4885 |
| US-20070270474-A1 | drugs have beta-amyloid peptide production inhibitory activity, such as 2-(2-benzo[b]thiophen-4-yl-acetylamino)-N-(5-phenyl-2H-pyrazol-3-yl)-propionamide, useful for treatment of Alzheimer's disease and Down's Syndrome | APP, BACE1, PSEN1 | POLB 2471/4885RAB9A 830/4885L3MBTL1 2526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.