Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21392348 | 0.84 | DGAT1 (0.37) | DGAT1CYP2D6CA2CA12CA14 | |
| SCHEMBL6179481 | 0.82 | LMNA (0.41) | DGAT1CYP2D6CA2CA12CA14 | |
| SCHEMBL241533 | 0.82 | DGAT1 (0.46) | DGAT1CYP2D6CA2CA12CA14 | |
| SCHEMBL19821874 | 0.80 | ALDH1A1 (0.32) | MCL1LMNATDP1GAA | |
| Methyl Alcohol SCHEMBL27995686 | 0.79 | DGAT1 (0.44) | DGAT1CYP2D6CA2CA12CA14 | |
| SCHEMBL1246384 | 0.79 | CTSD (0.39) | DGAT1CYP2D6CA2CA12CA14 | |
| SCHEMBL14957644 | 0.79 | CA2 (0.38) | DGAT1CYP2D6CA2CA12CA14 | |
| SCHEMBL24289242 | 0.79 | TSHR (0.43) | DGAT1CYP2D6CA2LMNATDP1 | |
| SCHEMBL28452577 | 0.77 | CAPN1 (0.39) | DGAT1CYP2D6CA2CA12CA14 | |
| SCHEMBL2648388 | 0.77 | DGAT1 (0.42) | DGAT1CYP2D6CA2CA12CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230132386-A9 | GRANZYME B DIRECTED IMAGING AND THERAPY | CYTOSITE BIOPHARMA INC. | 2023-04-27 | — | — | US | disclosed |
| US-20220135593-A1 | GRANZYME B DIRECTED IMAGING AND THERAPY | CYTOSITE BIOPHARMA INC (US) | 2022-05-05 | — | — | US | disclosed |
| WO-2017218633-A1 | 6-HYDROXY-5-(PHENYL/HETEROARYLSULFONYL)PYRIMIDIN-4(1H)-ONE AS APJ AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-12-21 | — | — | WO | disclosed |
| US-8901353-B2 | Polyimide precursor, polyimide, and liquid crystal aligning agent | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2014-12-02 | — | — | US | disclosed |
| US-20120088888-A1 | POLYIMIDE PRECURSOR, POLYIMIDE, AND LIQUID CRYSTAL ALIGNING AGENT | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2012-04-12 | — | — | US | disclosed |
| US-RE32491-E | BACTERICIDES | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1987-09-01 | — | — | US | disclosed |
| US-4404373-A | Process for the preparation of 7α-methoxy-7β-(1,3-diethietane-2-carboxamido)cephalosporanic acid derivatives | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1983-09-13 | — | — | US | disclosed |
| US-4263432-A | ANTIBIOTICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1981-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230132386-A9 | GRANZYME B DIRECTED IMAGING AND THERAPY | GZMB, PRF1, CTSB | DGAT1 2189/4885CYP2D6 3964/4885CA2 2075/4885 |
| US-20220135593-A1 | GRANZYME B DIRECTED IMAGING AND THERAPY | GZMB, PRF1, CTSB | DGAT1 2189/4885CYP2D6 3964/4885CA2 2075/4885 |
| US-20120088888-A1 | POLYIMIDE PRECURSOR, POLYIMIDE, AND LIQUID CRYSTAL ALIGNING AGENT | PUF60, F13A1, F12 | DGAT1 2416/4885CYP2D6 4845/4885CA2 1637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.