Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 4/20 | 0.69 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.69 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.69 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.69 |
| ▸ | C1S | P09871 | 1/20 | 0.57 |
| ▸ | F10 | P00742 | 1/20 | 0.56 |
| ▸ | F2 | P00734 | 7/20 | 0.53 |
| ▸ | PLG | P00747 | 1/20 | 0.52 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28278911 | 0.85 | PRSS1 (0.65) | PRSS1PRSS2PRSS3LOXL2C1S | |
| SCHEMBL28277477 | 0.82 | PRSS1 (0.61) | PRSS1PRSS2PRSS3LOXL2C1S | |
| SCHEMBL24358796 | 0.82 | PRSS1 (0.71) | PRSS1PRSS2PRSS3LOXL2C1S | |
| SCHEMBL4078620 | 0.82 | LOXL2 (1.00) | PRSS1PRSS2PRSS3LOXL2C1S | |
| SCHEMBL8542393 | 0.82 | PRSS1 (1.00) | PRSS1PRSS2PRSS3LOXL2C1S | |
| SCHEMBL18405471 | 0.82 | NOS1 (0.50) | PRSS1PRSS2PRSS3LOXL2NOS1 | |
| SCHEMBL27595727 | 0.81 | PRSS1 (0.65) | PRSS1PRSS2PRSS3LOXL2C1S | |
| SCHEMBL45866 | 0.80 | PARP1 (0.57) | LOXL2 | |
| SCHEMBL14714355 | 0.80 | PRSS1 (0.69) | PRSS1PRSS2PRSS3LOXL2C1S | |
| SCHEMBL14207821 | 0.80 | SMYD3 (0.44) | PRSS1PRSS2PRSS3LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169676-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | WASHINGTON UNIVERSITY (US) | 2022-06-02 | — | — | US | disclosed |
| US-11130780-B2 | Inhibitors of growth factor activation enzymes | WASHINGTON UNIVERSITY (US) | 2021-09-28 | — | — | US | disclosed |
| EP-3466961-A1 | PROLINAMIDE DERIVATIVE AS THROMBIN INHIBITOR, PREPARATION METHOD AND APPLICATION THEREOF | Li, Min (US) | 2019-04-10 | — | — | EP | disclosed |
| CN-109468659-A | The method of room temperature synthesizing benzimidazole under the conditions of electrocatalytic method water phase | 云南师范大学 | 2019-03-15 | — | — | CN | disclosed |
| CN-109456273-A | The method of benzenecarboximidamide class compound synthesis benzimidazole compound is used in microwave method water phase | 云南师范大学 | 2019-03-12 | — | — | CN | disclosed |
| US-20180066015-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | WASHINGTON UNIVERSITY (US) | 2018-03-08 | — | — | US | disclosed |
| US-20180036296-A1 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA | COR THERAPEUTICS, INC. | 2018-02-08 | — | — | US | disclosed |
| US-20170144984-A1 | MODULATORS OF THE RELAXIN RECEPTOR 1 | THE UNITED STATES OF AMERICA AS REPRESENTED BY SECRETARY DEPT OF HEALTH AND HUMAN SERVICE (US) | 2017-05-25 | — | — | US | disclosed |
| US-9629831-B2 | Benzamides and related inhibitors of factor XA | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-04-25 | — | — | US | disclosed |
| US-20160317511-A1 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA | COR THERAPEUTICS, INC. | 2016-11-03 | — | — | US | disclosed |
| US-9108922-B2 | Benzamides and related inhibitors of factor Xa | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-08-18 | — | — | US | disclosed |
| US-20140377247-A1 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-12-25 | — | — | US | disclosed |
| US-8691847-B2 | Benzamides and related inhibitors of factor Xa | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-04-08 | — | — | US | disclosed |
| US-20130172310-A1 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA | MILLENNIUM PHARMACEUTICALS, INC. | 2013-07-04 | — | — | US | disclosed |
| US-20120088758-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-04-12 | — | — | US | disclosed |
| US-20120083602-A1 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA | MILLENNIUM PHARMACEUTICALS, INC. | 2012-04-05 | — | — | US | disclosed |
| US-7453002-B2 | thrombotic or an inflammatory disorders; improved factor XIa and/or plasma kallikrein inhibitory activity and selectivity, dosage requirment, costs or feasibility, side effect reduction; 4-(aminomethyl)-N-[2-phenyl-1-(4-pyridin-2-yl-1H-imidazol-2-yl)ethyl]-trans-cyclohexanecarboxamide | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160317511-A1 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA | TFPI, F12, TFPI2 | PRSS1 29/4885PRSS2 47/4885PRSS3 88/4885 |
| US-20120088758-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | F12, F11, F5 | PRSS1 19/4885PRSS2 54/4885PRSS3 23/4885 |
| US-11130780-B2 | Inhibitors of growth factor activation enzymes | HDGF, MMP7, HGF | PRSS1 16/4885PRSS2 43/4885PRSS3 61/4885 |
| US-20220169676-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | HDGF, MMP7, HGF | PRSS1 16/4885PRSS2 43/4885PRSS3 61/4885 |
| US-20180036296-A1 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA | TFPI, F12, TFPI2 | PRSS1 29/4885PRSS2 47/4885PRSS3 88/4885 |
| US-20140377247-A1 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA | TFPI, F12, TFPI2 | PRSS1 29/4885PRSS2 47/4885PRSS3 88/4885 |
| US-20120083602-A1 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA | TFPI, F12, TFPI2 | PRSS1 29/4885PRSS2 47/4885PRSS3 88/4885 |
| US-20130172310-A1 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA | TFPI, F12, TFPI2 | PRSS1 29/4885PRSS2 47/4885PRSS3 88/4885 |
| US-20170144984-A1 | MODULATORS OF THE RELAXIN RECEPTOR 1 | RXFP1, RXFP2, RXFP3 | PRSS1 1107/4885PRSS2 2207/4885PRSS3 1838/4885 |
| US-20180066015-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | HDGF, MMP7, HGF | PRSS1 16/4885PRSS2 43/4885PRSS3 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.