Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 20/20 | 0.86 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.83 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.78 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167756 | 0.93 | ALOX5AP (0.89) | ALOX5APCYP2C9CYP3A4PTGS1ALOX5 | |
| SCHEMBL5537799 | 0.93 | ALOX5AP (0.74) | ALOX5APCYP2C9CYP3A4PTGS1ALOX5 | |
| SCHEMBL176084 | 0.92 | ALOX5AP (1.00) | ALOX5APCYP2C9CYP3A4PTGS1ALOX5 | |
| SCHEMBL176155 | 0.92 | ALOX5AP (0.84) | ALOX5APCYP2C9CYP3A4PTGS1ALOX5 | |
| SCHEMBL175670 | 0.91 | ALOX5AP (0.92) | ALOX5APCYP2C9CYP3A4PTGS1ALOX5 | |
| SCHEMBL3094559 | 0.91 | ALOX5AP (0.73) | ALOX5APCYP2C9CYP3A4PTGS1ALOX5 | |
| SCHEMBL176032 | 0.91 | ALOX5AP (1.00) | ALOX5APCYP2C9CYP3A4PTGS1ALOX5 | |
| SCHEMBL1722612 | 0.91 | ALOX5AP (0.81) | ALOX5APCYP2C9CYP3A4PTGS1ALOX5 | |
| SCHEMBL5529433 | 0.91 | ALOX5AP (0.79) | ALOX5APCYP2C9CYP3A4PTGS1ALOX5 | |
| SCHEMBL167707 | 0.91 | ALOX5AP (0.84) | ALOX5APCYP2C9CYP3A4PTGS1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200147064-A1 | Reduction of Pro-Inflammatory HDL Using a Leukotriene Inhibitor | AUTOIMMUNE PHARMA LLC (US) | 2020-05-14 | — | — | US | claimed |
| US-8399666-B2 | 5-lipoxygenase-activating protein (FLAP) inhibitors | PANMIRA PHARMACEUTICALS, LLC (US) | 2013-03-19 | — | — | US | claimed |
| US-20120232031-A1 | INJECTABLE FORMULATIONS FOR INTRA-ARTICULAR OR PERI-ARTICULAR ADMINISTRATION | PANMIRA PHARMACEUTICALS, LLC (US) | 2012-09-13 | — | — | US | claimed |
| EP-2490689-A2 | INJECTABLE FORMULATIONS FOR INTRA- ARTICULAR OR PERI-ARTICULAR ADMINISTRATION | Panmira Pharmaceuticals, LLC (US) | 2012-08-29 | — | — | EP | claimed |
| US-20120027842-A1 | TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR ADMINISTRATION TO AN EYE | AMIRA PHARMACEUTICALS, INC. (US) | 2012-02-02 | — | — | US | claimed |
| EP-2404904-A1 | 5-lipoxygenase-activating protein (FLAP) inhibitors | Amira Pharmaceuticals, Inc. (US) | 2012-01-11 | — | — | EP | claimed |
| US-20110311613-A1 | TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS | AMIRA PHARMACEUTICAL, INC. (US) | 2011-12-22 | — | — | US | claimed |
| EP-2381945-A2 | TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS | Amira Pharmaceuticals, Inc. (US) | 2011-11-02 | — | — | EP | claimed |
| EP-2379078-A2 | TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR ADMINISTRATION TO AN EYE | Amira Pharmaceuticals, Inc. (US) | 2011-10-26 | — | — | EP | claimed |
| WO-2011049979-A2 | INJECTABLE FORMULATIONS FOR INTRA- ARTICULAR OR PERI-ARTICULAR ADMINISTRATION | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-28 | — | — | WO | claimed |
| WO-2010075315-A2 | TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR ADMINISTRATION TO AN EYE | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-01 | — | — | WO | claimed |
| WO-2010075314-A2 | TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-01 | — | — | WO | claimed |
| US-20090192171-A1 | 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors | AMIRA PHARMACEUTICALS, INC. (US) | 2009-07-30 | — | — | US | claimed |
| US-20070219206-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-09-20 | — | — | US | claimed |
| US-20070105866-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-05-10 | — | — | US | claimed |
| US-20200147064-A1 | Reduction of Pro-Inflammatory HDL Using a Leukotriene Inhibitor | AUTOIMMUNE PHARMA LLC (US) | 2020-05-14 | — | — | US | disclosed |
| US-9688624-B2 | DP2 antagonist and uses thereof | BRICKELL BIOTECH, INC. (US) | 2017-06-27 | — | — | US | disclosed |
| US-20070219206-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-09-20 | — | — | US | disclosed |
| WO-2007056021-A2 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| US-20070105866-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105866-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | ALOX5, ALOX15B, ALOX15 | ALOX5AP 4/4885CYP2C9 2125/4885CYP3A4 912/4885 |
| US-20200147064-A1 | Reduction of Pro-Inflammatory HDL Using a Leukotriene Inhibitor | LTB4R, LTC4S, LTB4R2 | ALOX5AP 35/4885CYP2C9 619/4885CYP3A4 683/4885 |
| US-20090192171-A1 | 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors | ALOX5, ALOX15B, ALOX15 | ALOX5AP 4/4885CYP2C9 2125/4885CYP3A4 912/4885 |
| US-20120027842-A1 | TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR ADMINISTRATION TO AN EYE | FEN1, SERPINB1, EYA2 | ALOX5AP 100/4885CYP2C9 4727/4885CYP3A4 4571/4885 |
| US-20070219206-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | ALOX5, ALOX15B, ALOX15 | ALOX5AP 4/4885CYP2C9 2125/4885CYP3A4 912/4885 |
| US-20110311613-A1 | TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS | TSLP, SUCLG1, SERPINB1 | ALOX5AP 96/4885CYP2C9 4681/4885CYP3A4 4448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.