Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Benzoyl Formic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 14/20 | 0.68 |
| ▸ | CES1 | P23141 | 13/20 | 0.68 |
| ▸ | CA2 | P00918 | 2/20 | 0.59 |
| ▸ | CA4 | P22748 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | DAO | P14920 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoyl Formic Acid SCHEMBL1532670 | 0.97 | CES2 (0.65) | CES2CES1CA2CA4TSHR | |
| Benzoyl Formic Acid SCHEMBL1042299 | 0.97 | CES2 (0.65) | CES2CES1CA2CA4TSHR | |
| Benzoyl Formic Acid SCHEMBL1446195 | 0.97 | CES2 (0.65) | CES2CES1CA2CA4TSHR | |
| Benzoyl Formic Acid SCHEMBL8623983 | 0.97 | CES2 (0.65) | CES2CES1CA2CA4TSHR | |
| Benzoyl Formic Acid SCHEMBL3079821 | 0.97 | CES2 (0.65) | CES2CES1CA2CA4TSHR | |
| Benzoyl Formic Acid SCHEMBL5448316 | 0.97 | CES2 (0.65) | CES2CES1CA2CA4TSHR | |
| Benzoyl Formic Acid SCHEMBL699116 | 0.87 | CES2 (0.52) | CES2CES1CA2CA4TSHR | |
| Benzil SCHEMBL7142843 | 0.82 | CES2 (1.00) | CES2CES1CA2CA4TSHR | |
| Benzil SCHEMBL9517636 | 0.82 | CES2 (1.00) | CES2CES1CA2CA4TSHR | |
| Benzil SCHEMBL2156589 | 0.82 | CES2 (1.00) | CES2CES1CA2CA4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140100371-A1 | PROCESS FOR PREPARING AZOMETHINES FROM ALPHA-OXOCARBOXYLATES, AMINES AND ARYL BROMIDES | SALTIGO GMBH (DE) | 2014-04-10 | — | — | US | disclosed |
| EP-2640692-A1 | PROCESS FOR PREPARING AZOMETHINES FROM ALPHA-OXOCARBOXYLATES, AMINES AND ARYL BROMIDES | Saltigo GmbH (DE) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012066134-A1 | PROCESS FOR PREPARING AZOMETHINES FROM ALPHA-OXOCARBOXYLATES, AMINES AND ARYL BROMIDES | SALTIGO GMBH (DE) | 2012-05-24 | — | — | WO | disclosed |
| EP-2455364-A1 | Process for Preparing Azomethines from alpha-Oxocarboxylates, Amines and Aryl Bromides | Saltigo GmbH (DE) | 2012-05-23 | — | — | EP | disclosed |
| EP-2096101-B1 | Method for producing ketones from alpha-oxocarboxylates and aryl bromides | SALTIGO GMBH (DE) | 2012-04-18 | — | — | EP | disclosed |
| US-8022255-B2 | Process for preparing ketones from alpha-oxo carboxylates and aryl bromides | SALTIGO GMBH (DE) | 2011-09-20 | — | — | US | disclosed |
| US-20090221832-A1 | PROCESS FOR PREPARING KETONES FROM ALPHA-OXO CARBOXYLATES AND ARYL BROMIDES | SALTIGO GMBH (DE) | 2009-09-03 | — | — | US | disclosed |
| EP-2096101-A1 | Method for producing ketones from alpha-oxocarboxylates and aryl bromides | Saltigo GmbH (DE) | 2009-09-02 | — | — | EP | disclosed |
| EP-0788476-B1 | STILBENE DERIVATIVES USEFUL AS CYCLOOXYGENASE-2 INHIBITORS | MERCK FROSST CANADA INC (CA) | 1999-10-20 | — | — | EP | disclosed |
| US-5849943-A | Stilbene derivatives useful as cyclooxygenase-2 inhibitors | MERCK FROSST CANADA, INC. (CA) | 1998-12-15 | — | — | US | disclosed |
| EP-0788476-A1 | STILBENE DERIVATIVES USEFUL AS CYCLOOXYGENASE-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996013483-A1 | STILBENE DERIVATIVES USEFUL AS CYCLOOXYGENASE-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1996-05-09 | — | — | WO | disclosed |
| US-4638072-A | POLYAMIDES, POLYIMIDES | STANDARD OIL COMPANY (INDIANA) (US) | 1987-01-20 | — | — | US | disclosed |
| US-4596867-A | Disubstituted maleic anhydride compounds | STANDARD OIL COMPANY (INDIANA) (US) | 1986-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140100371-A1 | PROCESS FOR PREPARING AZOMETHINES FROM ALPHA-OXOCARBOXYLATES, AMINES AND ARYL BROMIDES | AOC2, AOC3, CBR1 | CES2 1794/4885CES1 3293/4885CA2 542/4885 |
| US-20090221832-A1 | PROCESS FOR PREPARING KETONES FROM ALPHA-OXO CARBOXYLATES AND ARYL BROMIDES | CBR1, CBR3, AKR1C3 | CES2 1854/4885CES1 2032/4885CA2 2089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.