Pivalate

Pivalate

SCHEMBL17025968

C=CC(=O)[O-].CC(C)(C)C(=O)[O-].CC(O)C[N+](C)(C)C.[K+]

nearest known ligand 0.39

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Known targets — ChEMBL curated mechanism

AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA

The experimentally established mechanism targets of Pivalate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC22A16 Q86VW1 1/20 0.39
BBOX1 O75936 2/20 0.33
CPT2 P23786 1/20 0.33
CPT1A P50416 1/20 0.33
MAPT P10636 2/20 0.32
TSHR P16473 2/20 0.31
CHRM2 P08172 2/20 0.31
CHRM4 P08173 2/20 0.31
CHRM1 P11229 2/20 0.31
TBXA2R P21731 1/20 0.31
MEN1 O00255 1/20 0.30
CYP1A2 P05177 1/20 0.30
HRH1 P35367 1/20 0.30
KMT2A Q03164 1/20 0.30
CRAT P43155 1/20 0.30
CHRM5 P08912 1/20 0.30
CHRM3 P20309 1/20 0.30
LMNA P02545 1/20 0.30
CYP2C9 P11712 1/20 0.30
GALR3 O60755 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acrylic Acid SCHEMBL7536808 0.88 SLC22A16 (0.45) SLC22A16BBOX1CPT2CPT1AMAPT
Acrylic Acid SCHEMBL7536805 0.88 SLC22A16 (0.45) SLC22A16BBOX1CPT2CPT1AMAPT
Pivalate SCHEMBL2354478 0.88 SLC22A16 (0.48) SLC22A16BBOX1CPT2CPT1AMAPT
Bicarbonate SCHEMBL28323257 0.75 SLC22A16 (0.56) SLC22A16BBOX1CPT2CPT1AMAPT
Acrylic Acid SCHEMBL7536810 0.74 MAPT (0.42) SLC22A16CPT2CPT1AMAPTTSHR
Methacrylic Acid SCHEMBL6678142 0.74 SLC22A16 (0.47) SLC22A16BBOX1CPT2CPT1AMAPT
Trichloroacetic Acid SCHEMBL9011588 0.74 SLC22A16 (0.47) SLC22A16BBOX1CPT2CPT1AMAPT
Pivalate SCHEMBL2354481 0.74 MAPT (0.45) SLC22A16CPT2CPT1AMAPTTSHR
Acetic Acid SCHEMBL5670671 0.73 SLC22A16 (0.54) SLC22A16BBOX1CPT2CPT1AMAPT
Bicarbonate SCHEMBL8320369 0.73 SLC22A16 (0.54) SLC22A16BBOX1CPT2CPT1AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3110546-B1 METHOD FOR MAKING A POLYISOCYANURATE/POLYURETHANE FOAM EVONIK OPERATIONS GMBH (DE) 2022-03-30 EP claimed
US-10125234-B2 Catalyst compositions and methods for making foam EVONIK DEGUSSA GMBH (DE) 2018-11-13 US claimed
EP-3110546-A1 CATALYST COMPOSITIONS AND METHODS FOR MAKING FOAM Air Products and Chemicals, Inc. (US) 2017-01-04 EP claimed
WO-2015130939-A1 CATALYST COMPOSITIONS AND METHODS FOR MAKING FOAM AIR PRODUCTS AND CHEMICALS, INC. (US) 2015-09-03 WO claimed
US-20150240023-A1 Catalyst Compositions and Methods for Making Foam AIR PRODUCTS AND CHEMICALS, INC. (US) 2015-08-27 US claimed
EP-3110546-B1 METHOD FOR MAKING A POLYISOCYANURATE/POLYURETHANE FOAM EVONIK OPERATIONS GMBH (DE) 2022-03-30 EP disclosed
US-10125234-B2 Catalyst compositions and methods for making foam EVONIK DEGUSSA GMBH (DE) 2018-11-13 US disclosed
EP-3110546-A1 CATALYST COMPOSITIONS AND METHODS FOR MAKING FOAM Air Products and Chemicals, Inc. (US) 2017-01-04 EP disclosed
WO-2015130939-A1 CATALYST COMPOSITIONS AND METHODS FOR MAKING FOAM AIR PRODUCTS AND CHEMICALS, INC. (US) 2015-09-03 WO disclosed
US-20150240023-A1 Catalyst Compositions and Methods for Making Foam AIR PRODUCTS AND CHEMICALS, INC. (US) 2015-08-27 US disclosed