Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | CFD | P00746 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17069843 | 0.80 | L3MBTL1 (0.38) | ALDH1A1GAAPOLBLMNAMAPT | |
| SCHEMBL21617916 | 0.80 | ALDH1A1 (0.44) | ACLYCYP4F2CYP4A11HSP90AB1ALDH1A1 | |
| SCHEMBL480112 | 0.79 | MEN1 (0.44) | ACLYCYP4F2CYP4A11ALDH1A1POLB | |
| SCHEMBL27748507 | 0.78 | MAPT (0.43) | ACLYHSP90AB1ALDH1A1KDM4EGAA | |
| SCHEMBL1626544 | 0.75 | PNMT (0.48) | ALDH1A1KDM4ENPC1RAB9AHPGD | |
| SCHEMBL27856549 | 0.75 | TRPV1 (0.40) | ACLYCYP4F2CYP4A11HSP90AB1ALDH1A1 | |
| SCHEMBL17069844 | 0.73 | CLCN2 (0.39) | — | |
| SCHEMBL3623804 | 0.73 | CYP1A2 (0.54) | CYP4F2CYP4A11HSP90AB1ALDH1A1KDM4E | |
| SCHEMBL30776972 | 0.73 | CYP1A2 (0.54) | CYP4F2CYP4A11HSP90AB1ALDH1A1KDM4E | |
| SCHEMBL11462248 | 0.72 | LMNA (0.49) | KDM4EEGFRSMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200262850-A1 | SUBSTITUTED ASYMMETRIC UREAS AS MODULATORS OF GHRELIN RECEPTOR ACTIVITY | HELSINN HEALTHCARE SA (CH) | 2020-08-20 | — | — | US | disclosed |
| EP-3114118-B1 | P-SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2020-07-22 | — | — | EP | disclosed |
| US-10577384-B2 | Substituted asymmetric ureas as modulators of ghrelin receptor activity | HELSINN HEALTHCARE SA (CH) | 2020-03-03 | — | — | US | disclosed |
| US-9926337-B2 | Substituted asymmetric ureas as modulators of ghrelin receptor activity | HELSINN HEALTHCARE SA (CH) | 2018-03-27 | — | — | US | disclosed |
| US-20170145038-A1 | SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2017-05-25 | — | — | US | disclosed |
| US-9546157-B2 | Asymmetric piperidinyl-substituted ureas as medicines | HELSINN HEALTHCARE SA (CH) | 2017-01-17 | — | — | US | disclosed |
| WO-2015134839-A1 | P-SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2015-09-11 | — | — | WO | disclosed |
| US-20150252021-A1 | p-Substituted Asymmetric Ureas and Medical Uses Thereof | HELSINN HEALTHCARE SA (CH) | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10577384-B2 | Substituted asymmetric ureas as modulators of ghrelin receptor activity | GHSR, GIPR, UTS2R | ACLY 3091/4885CYP4F2 2630/4885CYP4A11 2548/4885 |
| US-20150252021-A1 | p-Substituted Asymmetric Ureas and Medical Uses Thereof | UTS2R, GIPR, GPR119 | ACLY 1834/4885CYP4F2 1890/4885CYP4A11 1933/4885 |
| US-20200262850-A1 | SUBSTITUTED ASYMMETRIC UREAS AS MODULATORS OF GHRELIN RECEPTOR ACTIVITY | GHSR, GIPR, UTS2R | ACLY 3091/4885CYP4F2 2630/4885CYP4A11 2548/4885 |
| US-20170145038-A1 | SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF | UTS2R, GHSR, GPR119 | ACLY 1715/4885CYP4F2 1666/4885CYP4A11 2010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.